UniProt Accession

 PRP31_MOUSE; Q8CCF0; E9QPM6; Q6P7X2; Q8BQ91; Q8C8U4; Q8C8V5; Q8CCG6; Q8CF52; Q8VBW3 

Genbank Protein ID

 AY040823; AK005294; AK033190; AK033283; AK044398; AK044457; AK051260; CT010189; AC130680; BC018376; BC057877; BC061461 

Genbank Nucleotide ID

 AAK77987.1; BAC25109.1; BAC28192.1; BAC28220.1; BAC31903.1; BAC31931.1; BAC34578.1; CAJ18397.1; AAH18376.1; AAH57877.1; AAH61461.1 

Protein Name

 U4/U6 small nuclear ribonucleoprotein Prp31 

Protein Synonyms/Alias

 Pre-mRNA-processing factor 31; U4/U6 snRNP 61 kDa protein; Protein 61K 

Gene Name

 Prpf31 

Gene Synonyms/Alias

 Prp31 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
341	PPPVKQVKPLPAPLD	acetylation	[1]
438	QSVVYGGKSTIRDRS	acetylation	[2]
478	KVAEANQKYFSSMAE	acetylation	[3]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Involved in pre-mRNA splicing. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (By similarity). 

Sequence Annotation

 DOMAIN 215 333 Nop.
 REGION 351 364 Nuclear localization signal (NLS) (By
 MOD_RES 379 379 Phosphoserine (By similarity).
 MOD_RES 450 450 Phosphoserine (By similarity).
 MOD_RES 455 455 Phosphothreonine (By similarity).  

Keyword

 Alternative splicing; Coiled coil; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Ribonucleoprotein; RNA-binding; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 499 AA 

Protein Sequence

Gene Ontology

 GO:0015030; C:Cajal body; ISA:MGI.
 GO:0071339; C:MLL1 complex; ISS:UniProtKB.
 GO:0016607; C:nuclear speck; ISA:MGI.
 GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
 GO:0005687; C:U4 snRNP; IEA:Compara.
 GO:0046540; C:U4/U6 x U5 tri-snRNP complex; ISA:MGI.
 GO:0043021; F:ribonucleoprotein complex binding; ISA:MGI.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0070990; F:snRNP binding; IEA:Compara.
 GO:0000244; P:assembly of spliceosomal tri-snRNP; ISA:MGI. 

Interpro

 IPR002687; Nop_dom.
 IPR012976; NOSIC.
 IPR027105; Prp31.
 IPR019175; Prp31_C. 

Pfam

 PF01798; Nop
 PF08060; NOSIC
 PF09785; Prp31_C 

SMART

 SM00931; NOSIC 

PROSITE

 PS51358; NOP 

PRINTS