| Tag | Content |
|---|
| CPLM ID | CPLM-002808 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Pheromone-processing carboxypeptidase KEX1 |
Protein Synonyms/Alias | Carboxypeptidase D; Killer expression defective protein 1 |
Gene Name | KEX1 |
Gene Synonyms/Alias | YGL203C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 152 | GFSVEQNKDEGKIDK | ubiquitination | [1] |
|
Reference | [1] Identification, analysis, and prediction of protein ubiquitination sites. Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM. Proteins. 2010 Feb 1;78(2):365-80. [ PMID: 19722269] |
Functional Description | Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from the precursors of K1, K2 and K28 killer toxins and a-factor (mating pheromone). Involved in the programmed cell death caused by defective N-glycosylation and contributes also to the active cell death program induced by acetic acid stress or during chronological aging. Promotes cell fusion by proteolytically processing substrates that act in parallel to PRM1 as an alternative fusion machine, as cell wall components, or both. |
Sequence Annotation | ACT_SITE 198 198
ACT_SITE 405 405 By similarity.
ACT_SITE 470 470 By similarity.
CARBOHYD 81 81 N-linked (GlcNAc...) (Potential).
CARBOHYD 459 459 N-linked (GlcNAc...).
CARBOHYD 467 467 N-linked (GlcNAc...). |
Keyword | 3D-structure; Apoptosis; Carboxypeptidase; Complete proteome; Glycoprotein; Golgi apparatus; Hydrolase; Membrane; Protease; Reference proteome; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 729 AA |
Protein Sequence | MFYNRWLGTW LAMSALIRIS VSLPSSEEYK VAYELLPGLS EVPDPSNIPQ MHAGHIPLRS 60
EDADEQDSSD LEYFFWKFTN NDSNGNVDRP LIIWLNGGPG CSSMDGALVE SGPFRVNSDG 120
KLYLNEGSWI SKGDLLFIDQ PTGTGFSVEQ NKDEGKIDKN KFDEDLEDVT KHFMDFLENY 180
FKIFPEDLTR KIILSGESYA GQYIPFFANA ILNHNKFSKI DGDTYDLKAL LIGNGWIDPN 240
TQSLSYLPFA MEKKLIDESN PNFKHLTNAH ENCQNLINSA STDEAAHFSY QECENILNLL 300
LSYTRESSQK GTADCLNMYN FNLKDSYPSC GMNWPKDISF VSKFFSTPGV IDSLHLDSDK 360
IDHWKECTNS VGTKLSNPIS KPSIHLLPGL LESGIEIVLF NGDKDLICNN KGVLDTIDNL 420
KWGGIKGFSD DAVSFDWIHK SKSTDDSEEF SGYVKYDRNL TFVSVYNASH MVPFDKSLVS 480
RGIVDIYSND VMIIDNNGKN VMITTDDDSD QDATTESGDK PKENLEEEEQ EAQNEEGKEK 540
EGNKDKDGDD DNDNDDDDED DHNSEGDDDD DDDDDEDDNN EKQSNQGLED SRHKSSEYEQ 600
EEEEVEEFAE EISMYKHKAV VVTIVTFLIV VLGVYAYDRR VRRKARHTIL VDPNNRQHDS 660
PNKTVSWADD LESGLGAEDD LEQDEQLEGG APISSTSNKA GSKLKTKKKK KYTSLPNTEI 720
DESFEMTDF 729 |
Gene Ontology | GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005802; C:trans-Golgi network; IDA:SGD. GO:0004185; F:serine-type carboxypeptidase activity; TAS:SGD. GO:0006915; P:apoptotic process; IMP:SGD. GO:0006508; P:proteolysis; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |