| Tag | Content |
|---|
| CPLM ID | CPLM-010994 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ras association domain-containing protein 7 |
Protein Synonyms/Alias | HRAS1-related cluster protein 1 |
Gene Name | RASSF7 |
Gene Synonyms/Alias | C11orf13; HRC1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 115 | IRASLPVKPRAALGC | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti- apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization. |
Sequence Annotation | DOMAIN 6 89 Ras-associating. |
Keyword | Alternative splicing; Apoptosis; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Polymorphism; Reference proteome; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 373 AA |
Protein Sequence | MLLGLAAMEL KVWVDGIQRV VCGVSEQTTC QEVVIALAQA IGQTGRFVLV QRLREKERQL 60
LPQECPVGAQ ATCGQFASDV QFVLRRTGPS LAGRPSSDSC PPPERCLIRA SLPVKPRAAL 120
GCEPRKTLTP EPAPSLSRPG PAAPVTPTPG CCTDLRGLEL RVQRNAEELG HEAFWEQELR 180
REQAREREGQ ARLQALSAAT AEHAARLQAL DAQARALEAE LQLAAEAPGP PSPMASATER 240
LHQDLAVQER QSAEVQGSLA LVSRALEAAE RALQAQAQEL EELNRELRQC NLQQFIQQTG 300
AALPPPPRPD RGPPGTQGPL PPAREESLLG APSESHAGAQ PRPRGGPHDA ELLEVAAAPA 360
PEWCPLAAQP QAL 373 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; NAS:UniProtKB. GO:0003677; F:DNA binding; NAS:UniProtKB. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0006355; P:regulation of transcription, DNA-dependent; NAS:UniProtKB. GO:0007165; P:signal transduction; IEA:InterPro. |
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Pfam | |
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PRINTS | |