UniProt Accession

 HPCL1_HUMAN; P37235; Q969S5 

Genbank Protein ID

 D16227; BC009846; BC017028; BC017482 

Genbank Nucleotide ID

 BAA03754.1; AAH09846.1; AAH17028.1; AAH17482.1 

Protein Name

 Hippocalcin-like protein 1 

Protein Synonyms/Alias

 Calcium-binding protein BDR-1; HLP2; Visinin-like protein 3; VILIP-3 

Gene Name

 HPCAL1 

Gene Synonyms/Alias

 BDR1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
7	*MGKQNSKLRPEVLQ	ubiquitination	[1, 2]
63	FPYGDASKFAEHVFR	ubiquitination	[1, 2]
137	KMVSSVMKMPEDEST	ubiquitination	[3]
174	EEFIRGAKSDPSIVR	ubiquitination	[3, 4]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. 

Sequence Annotation

 DOMAIN 23 58 EF-hand 1.
 DOMAIN 60 95 EF-hand 2.
 DOMAIN 96 131 EF-hand 3.
 DOMAIN 144 179 EF-hand 4.
 LIPID 2 2 N-myristoyl glycine (By similarity).  

Keyword

 Calcium; Complete proteome; Lipoprotein; Metal-binding; Myristate; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 193 AA 

Protein Sequence

Gene Ontology

 GO:0005509; F:calcium ion binding; TAS:ProtInc. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR001125; Recoverin. 

Pfam

 PF13499; EF_hand_5 

SMART

 SM00054; EFh 

PROSITE

 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 

PRINTS

 PR00450; RECOVERIN.