CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013718
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable glycine dehydrogenase [decarboxylating] subunit 1 
Protein Synonyms/Alias
 Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1 
Gene Name
 gcvPA 
Gene Synonyms/Alias
 GK2424 
Created Date
 July 27, 2013 
Organism
 Geobacillus kaustophilus (strain HTA426) 
NCBI Taxa ID
 235909 
Lysine Modification
Position
Peptide
Type
References
184KGQKLEVKEIPYDGGacetylation[1]
352ALGKRGVKEMAAMNIacetylation[1]
Reference
 [1] Proteomic analysis of acetylation in thermophilic Geobacillus kaustophilus.
 Lee DW, Kim D, Lee YJ, Kim JA, Choi JY, Kang S, Pan JG.
 Proteomics. 2013 Aug;13(15):2278-82. [PMID: 23696451] 
Functional Description
 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Oxidoreductase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 448 AA 
Protein Sequence
MLHRYLPMTE EDKQEMLKTI GVASIDDLFA DIPEQVRFRG ELKVKPAKSE PELWKELAAL 60
AEKNASVKQY VSFLGAGVYD HYIPAVVDHV LSRSEFYTAY TPYQPEISQG ELQAIFEFQT 120
MVCELTGMDV ANSSMYDGGT ALAEAVLLSA AHTKRKKVLI STAVHPQYRE VVRTYAKGQK 180
LEVKEIPYDG GITDLKALEA EMGDDVACVV VQYPNFFGQI EPLKAIAPLA HEKKSLFVVA 240
SNPLALGVLT PPGAFGADIV VGDMQPFGIP TQFGGPHCGY FAVKAPLMRK IPGRLVGQTT 300
DEDGRRGFVL TLQAREQHIR RDKATSNICS NQALNALAAS VALSALGKRG VKEMAAMNIQ 360
KAHYAKVELE KRGLSSPFAG PFFNEFVIRL GRPVSDVNDR LLEKGIIGGY DLGADYPELA 420
GHMLVAVTEL RTKEEIDRFV NELGDGHA 448 
Gene Ontology
 GO:0004375; F:glycine dehydrogenase (decarboxylating) activity; IEA:EC.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0006546; P:glycine catabolic process; IEA:InterPro.
 GO:0009116; P:nucleoside metabolic process; IEA:InterPro. 
Interpro
 IPR020580; GDC-P_N.
 IPR020581; GDC_P.
 IPR023010; GDC_P_su1.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1. 
Pfam
 PF02347; GDC-P 
SMART
  
PROSITE
  
PRINTS