| Tag | Content |
|---|
| CPLM ID | CPLM-004310 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Aspartate--tRNA ligase, cytoplasmic |
Protein Synonyms/Alias | Aspartyl-tRNA synthetase; AspRS |
Gene Name | Dars |
Gene Synonyms/Alias | Drs1 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 103 | HASKQMVKFAANINK | acetylation | [1] | | 451 | HHGIDLEKIKAYIDS | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. |
Sequence Annotation | MOD_RES 74 74 N6-acetyllysine (By similarity).
MOD_RES 249 249 Phosphoserine (By similarity).
MOD_RES 374 374 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding; Phosphoprotein; Protein biosynthesis; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 501 AA |
Protein Sequence | MPSANASRKG QEKPREIVDA AEDYAKERYG VSSMIQSQEK PDRVLVRVKD LTVQKADEVV 60
WVRARVHTSR AKGKQCFLVL RQQQFNVQAL VAVGDHASKQ MVKFAANINK ESIIDVEGIV 120
RKVNQKIGSC TQQDVELHVQ KIYVISLAEP RLPLQLDDAI RPEVEGEEDG RATVNQDTRL 180
DNRIIDLRTS TSQAIFHLQS GICHLFRETL INKGFVEIQT PKIISAASEG GANVFTVSYF 240
KSNAYLAQSP QLYKQMCICA DFEKVFCIGP VFRAEDSNTH RHLTEFVGLD IEMAFNYHYH 300
EVVEEIADTL VQIFKGLQER FQTEIQTVNK QFPCEPFKFL EPTLRLEYCE ALAMLREAGV 360
EMDDEEDLST PNEKLLGRLV KEKYDTDFYV LDKYPLAVRP FYTMPDPRNP KQSNSYDMFM 420
RGEEILSGAQ RIHDPQLLTE RALHHGIDLE KIKAYIDSFR FGAPPHAGGG IGLERVTMLF 480
LGLHNVRQTS MFPRDPKRLT P 501 |
Gene Ontology | GO:0017101; C:aminoacyl-tRNA synthetase multienzyme complex; TAS:RGD. GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0004815; F:aspartate-tRNA ligase activity; IEA:EC. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0003676; F:nucleic acid binding; IEA:InterPro. GO:0006422; P:aspartyl-tRNA aminoacylation; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |