| Tag | Content |
|---|
| CPLM ID | CPLM-021024 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | GMP reductase 1 |
Protein Synonyms/Alias | Guanosine 5'-monophosphate oxidoreductase 1; Guanosine monophosphate reductase 1 |
Gene Name | Gmpr |
Gene Synonyms/Alias | Gmpr1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 276 | MSSDTAMKKHAGGVA | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity). |
Sequence Annotation | NP_BIND 108 131 NADP (By similarity).
ACT_SITE 186 186 Thioimidate intermediate (By similarity).
METAL 181 181 Potassium; via carbonyl oxygen (By
METAL 183 183 Potassium; via carbonyl oxygen (By
BINDING 219 219 NADP (By similarity). |
Keyword | Complete proteome; Metal-binding; NADP; Oxidoreductase; Potassium; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 345 AA |
Protein Sequence | MPRIDADLKL DFKDVLLRPK RSSLKSRSEV DLERTFTFRN SKQTYSGIPI IVANMDTVGT 60
FEMAVVMSQH AMFTAVHKHY SLDDWKCFAE THPECLQHVA VSSGSGQNDL ERMSRILEAV 120
PQVKFICLDV ANGYSEHFVE FVKLVRSKFP EHTIMAGNVV TGEMVEELIL SGADIIKVGV 180
GPGSVCTTRT KTGVGYPQLS AVIECADSAH GLKGHIISDG GCTCPGDVAK AFGAGADFVM 240
LGGMFSGHTE CAGEVIERNG QKLKLFYGMS SDTAMKKHAG GVAEYRASEG KTVEVPYKGD 300
VENTILDILG GLRSTCTYVG AAKLKELSRR ATFIRVTQQH NTVFG 345 |
Gene Ontology | GO:0003920; F:GMP reductase activity; IEA:EC. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0009117; P:nucleotide metabolic process; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |