UniProt Accession

 CBX5_MOUSE; Q61686; Q9CS35; Q9CXD1 

Genbank Protein ID

 X99641; AF216290; AK008792; AK018349; AK030366; AK030442; AK032975; AK019198; BC004707 

Genbank Nucleotide ID

 CAA67960.1; AAF80993.1; BAB25897.1; BAB31173.1; BAC26923.1; BAC26966.1; BAC28107.1; BAB31596.1; AAH04707.1 

Protein Name

 Chromobox protein homolog 5 

Protein Synonyms/Alias

 Heterochromatin protein 1 homolog alpha; HP1 alpha 

Gene Name

 Cbx5 

Gene Synonyms/Alias

 Hp1a 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
68	ELISEFMKKYKKMKE	acetylation	[1]
68	ELISEFMKKYKKMKE	ubiquitination	[2]
84	ENNKPREKSEGNKRK	sumoylation	[3]
102	SNSADDIKSKKKREQ	acetylation	[1]
102	SNSADDIKSKKKREQ	ubiquitination	[2]
125	ERGLEPEKIIGATDS	ubiquitination	[2]
143	LMFLMKWKDTDEADL	ubiquitination	[2]
154	EADLVLAKEANVKCP	ubiquitination	[2]
159	LAKEANVKCPQIVIA	ubiquitination	[2]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] SUMOylation promotes de novo targeting of HP1α to pericentric heterochromatin.
 Maison C, Bailly D, Roche D, Montes de Oca R, Probst AV, Vassias I, Dingli F, Lombard B, Loew D, Quivy JP, Almouzni G.
 Nat Genet. 2011 Mar;43(3):220-7. [PMID: 21317888] 

Functional Description

 Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins (By similarity). 

Sequence Annotation

 DOMAIN 20 78 Chromo 1.
 DOMAIN 121 179 Chromo 2; shadow subtype.
 MOD_RES 8 8 Phosphothreonine (By similarity).
 MOD_RES 11 11 Phosphoserine.
 MOD_RES 12 12 Phosphoserine.
 MOD_RES 13 13 Phosphoserine.
 MOD_RES 14 14 Phosphoserine.
 MOD_RES 92 92 Phosphoserine.
 MOD_RES 93 93 Phosphoserine.
 MOD_RES 97 97 Phosphoserine (By similarity).
 MOD_RES 110 110 Phosphoserine (By similarity).  

Keyword

 Centromere; Chromosome; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 191 AA 

Protein Sequence

Gene Ontology

 GO:0010369; C:chromocenter; IDA:MGI.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0000118; C:histone deacetylase complex; IDA:BHF-UCL.
 GO:0035097; C:histone methyltransferase complex; IDA:BHF-UCL.
 GO:0000776; C:kinetochore; IDA:MGI.
 GO:0005720; C:nuclear heterochromatin; IDA:MGI.
 GO:0005730; C:nucleolus; IDA:MGI.
 GO:0016605; C:PML body; IEA:Compara.
 GO:0017053; C:transcriptional repressor complex; IDA:BHF-UCL.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0035064; F:methylated histone residue binding; ISS:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:MGI. 

Interpro

 IPR017984; Chromo_dom_subgr.
 IPR023780; Chromo_domain.
 IPR000953; Chromo_domain/shadow.
 IPR008251; Chromo_shadow_dom.
 IPR016197; Chromodomain-like.
 IPR023779; Chromodomain_CS. 

Pfam

 PF00385; Chromo
 PF01393; Chromo_shadow 

SMART

 SM00298; CHROMO
 SM00300; ChSh 

PROSITE

 PS00598; CHROMO_1
 PS50013; CHROMO_2 

PRINTS

 PR00504; CHROMODOMAIN.