CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002088
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Argininosuccinate lyase 
Protein Synonyms/Alias
 ASAL; Arginosuccinase 
Gene Name
 ARG4 
Gene Synonyms/Alias
 YHR018C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
33ASLPYDYKMYKADLEubiquitination[1]
36PYDYKMYKADLEGTKubiquitination[1]
43KADLEGTKVYTAGLQacetylation[2]
43KADLEGTKVYTAGLQubiquitination[1]
51VYTAGLQKLGLLTETacetylation[2]
290SSLMPQKKNADSLELacetylation[2]
418LTLEQYQKIDSRFGQacetylation[2]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
  
Sequence Annotation
 MOD_RES 27 27 Phosphoserine.  
Keyword
 Amino-acid biosynthesis; Arginine biosynthesis; Complete proteome; Lyase; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 463 AA 
Protein Sequence
MSDGTQKLWG GRFTGETDPL MHLYNASLPY DYKMYKADLE GTKVYTAGLQ KLGLLTETEL 60
AKIHEGLAEI KKEWDADKFV RHPNDEDIHT ANERRLGELI GRDIAGKVHT GRSRNDQVVT 120
DLRIYCRDIV NDTLFPALKG LVEVLIKRAE GEIDVLMPGY THLQRAQPIR WSHWLSSYAT 180
YFTEDYKRLG QILHRLNQSP LGAGALAGHP YGIDREFLAE GLGFNSVIGN SLVAVSDRDF 240
IVELMFWGTL FMNHISRFAE DLIIYCTAEF GFIQLSDAYS TGSSLMPQKK NADSLELLRG 300
KSGRVFGDLT GFLMSLKGIP STYDKDMQED KEPLFDCLTT VEHSMLIATG VISTLTVNKE 360
KMEAALTMDM LATDLADYLV RKGVPFRETH HISGECVATA ERLGLSGIDK LTLEQYQKID 420
SRFGQDLFET FNFEQSVERR DATGGTAKSA VLKQLDNLKS QLN 463 
Gene Ontology
 GO:0005829; C:cytosol; IDA:SGD.
 GO:0004056; F:argininosuccinate lyase activity; IDA:SGD.
 GO:0042450; P:arginine biosynthetic process via ornithine; IDA:SGD. 
Interpro
 IPR009049; Argininosuccinate_lyase.
 IPR003031; D_crystallin.
 IPR024083; Fumarase/histidase_N.
 IPR000362; Fumarate_lyase.
 IPR020557; Fumarate_lyase_CS.
 IPR022761; Fumarate_lyase_N.
 IPR008948; L-Aspartase-like. 
Pfam
 PF00206; Lyase_1 
SMART
  
PROSITE
 PS00163; FUMARATE_LYASES 
PRINTS
 PR00145; ARGSUCLYASE.
 PR00149; FUMRATELYASE.