| Tag | Content |
|---|
| CPLM ID | CPLM-013623 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Serine/threonine-protein phosphatase 6 regulatory subunit 3 |
Protein Synonyms/Alias | SAPS domain family member 3; Sporulation-induced transcript 4-associated protein SAPL |
Gene Name | PPP6R3 |
Gene Synonyms/Alias | C11orf23; KIAA1558; PP6R3; SAPL; SAPS3 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 190 | LNWLNEEKIIQRLVE | ubiquitination | [1] | | 446 | EAWEMNEKKQAEGGR | ubiquitination | [1] | | 486 | ALVQQLIKDLPDEVR | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance. |
Sequence Annotation | MOD_RES 579 579 Phosphoserine.
MOD_RES 617 617 Phosphoserine.
MOD_RES 722 722 Phosphoserine.
MOD_RES 853 853 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 873 AA |
Protein Sequence | MFWKFDLHSS SHIDTLLERE DVTLKELMDE EDVLQECKAQ NRKLIEFLLK AECLEDLVSF 60
IIEEPPQDMD EKIRYKYPNI SCELLTSDVS QMNDRLGEDE SLLMKLYSFL LNDSPLNPLL 120
ASFFSKVLSI LISRKPEQIV DFLKKKHDFV DLIIKHIGTS AIMDLLLRLL TCIEPPQPRQ 180
DVLNWLNEEK IIQRLVEIVH PSQEEDRHSN ASQSLCEIVR LSRDQMLQIQ NSTEPDPLLA 240
TLEKQEIIEQ LLSNIFHKEK NESAIVSAIQ ILLTLLETRR PTFEGHIEIC PPGMSHSACS 300
VNKSVLEAIR GRLGSFHELL LEPPKKSVMK TTWGVLDPPV GNTRLNVIRL ISSLLQTNTS 360
SINGDLMELN SIGVILNMFF KYTWNNFLHT QVEICIALIL ASPFENTENA TITDQDSTGD 420
NLLLKHLFQK CQLIERILEA WEMNEKKQAE GGRRHGYMGH LTRIANCIVH STDKGPNSAL 480
VQQLIKDLPD EVRERWETFC TSSLGETNKR NTVDLVTTCH IHSSSDDEID FKETGFSQDS 540
SLQQMQQMTS NFIDQFGFND EKFADQDDIG NVSFDRVSDI NFTLNTNESG NIALFEACCK 600
ERIQQFDDGG SDEEDIWEEK HIAFTPESQR RSSSGSTDSE ESTDSEEEDG AKQDLFEPSS 660
ANTEDKMEVD LSEPPNWSAN FDVPMETTHG APLDSVGSDV WSTEEPMPTK ETGWASFSEF 720
TSSLSTKDSL RSNSPVEMET STEPMDPLTP SAAALAVQPE AAGSVAMEAS SDGEEDAEST 780
DKVTETVMNG GMKETLSLTV DAKTETAVFK SEEGKLSTSQ DAACKDAEEC PETAEAKCAA 840
PRPPSSSPEQ RTGQPSAPGD TSVNGPV 867 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0043666; P:regulation of phosphoprotein phosphatase activity; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |