UniProt Accession

 CSN1_HUMAN; Q13098; Q8NA10; Q9BWL1 

Genbank Protein ID

 U20285; AK093283; AC135056; BC000155; BC064503; BT009834 

Genbank Nucleotide ID

 AAC50906.2; BAC04120.1; AAH00155.3; AAH64503.1; AAP88836.1 

Protein Name

 COP9 signalosome complex subunit 1 

Protein Synonyms/Alias

 SGN1; Signalosome subunit 1; G protein pathway suppressor 1; GPS-1; JAB1-containing signalosome subunit 1; Protein MFH 

Gene Name

 GPS1 

Gene Synonyms/Alias

 COPS1; CSN1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
144	KALLKLEKLDTDLKN	ubiquitination	[1]
150	EKLDTDLKNYKGNSI	ubiquitination	[1, 2]
153	DTDLKNYKGNSIKES	ubiquitination	[1]
158	NYKGNSIKESIRRGH	ubiquitination	[1]
183	GDLSNALKCYSRARD	ubiquitination	[2]
224	HVLSYVSKAESTPEI	ubiquitination	[1]
248	QTQAILTKLKCAAGL	ubiquitination	[1, 2]
317	VISSSSFKLFLELEP	ubiquitination	[1]
422	ARVDSHSKILYARDV	ubiquitination	[1, 2]
438	QRSTTFEKSLLMGKE	ubiquitination	[1, 2]
444	EKSLLMGKEFQRRAK	ubiquitination	[1, 2]
467	LRNQIHVKSPPREGS	acetylation	[3]
467	LRNQIHVKSPPREGS	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction. 

Sequence Annotation

 DOMAIN 324 428 PCI.
 MOD_RES 468 468 Phosphoserine.
 MOD_RES 474 474 Phosphoserine.
 MOD_RES 479 479 Phosphothreonine.
 MOD_RES 483 483 Phosphoserine.  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome; Signalosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 491 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0008180; C:signalosome; IDA:UniProtKB.
 GO:0005095; F:GTPase inhibitor activity; TAS:ProtInc.
 GO:0007049; P:cell cycle; TAS:ProtInc.
 GO:0010388; P:cullin deneddylation; IDA:UniProtKB.
 GO:0000188; P:inactivation of MAPK activity; TAS:ProtInc.
 GO:0007254; P:JNK cascade; TAS:ProtInc. 

Interpro

 IPR019585; 26S_proteasome_reg_su-Rpn7.
 IPR000717; PCI_dom.
 IPR011990; TPR-like_helical.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF01399; PCI
 PF10602; RPN7 

SMART

 SM00088; PINT 

PROSITE

  

PRINTS