| Tag | Content |
|---|
| CPLM ID | CPLM-000462 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Calpain-5 |
Protein Synonyms/Alias | Calpain htra-3; New calpain 3; nCL-3 |
Gene Name | CAPN5 |
Gene Synonyms/Alias | NCL3 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 42 | TDDSLYYKGTPGPAV | ubiquitination | [1] | | 273 | HGLLAFFKSEKLDMI | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | |
Sequence Annotation | DOMAIN 26 343 Calpain catalytic.
DOMAIN 518 619 C2.
REGION 344 496 Domain III.
ACT_SITE 81 81 By similarity.
ACT_SITE 252 252 By similarity.
ACT_SITE 284 284 By similarity. |
Keyword | Complete proteome; Disease mutation; Hydrolase; Protease; Reference proteome; Thiol protease. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 640 AA |
Protein Sequence | MFSCVKPYED QNYSALRRDC RRRKVLFEDP LFPATDDSLY YKGTPGPAVR WKRPKGICED 60
PRLFVDGISS HDLHQGQVGN CWFVAACSSL ASRESLWQKV IPDWKEQEWD PEKPNAYAGI 120
FHFHFWRFGE WVDVVIDDRL PTVNNQLIYC HSNSRNEFWC ALVEKAYAKL AGCYQALDGG 180
NTADALVDFT GGVSEPIDLT EGDFANDETK RNQLFERMLK VHSRGGLISA SIKAVTAADM 240
EARLACGLVK GHAYAVTDVR KVRLGHGLLA FFKSEKLDMI RLRNPWGERE WNGPWSDTSE 300
EWQKVSKSER EKMGVTVQDD GEFWMTFEDV CRYFTDIIKC RVINTSHLSI HKTWEEARLH 360
GAWTLHEDPR QNRGGGCINH KDTFFQNPQY IFEVKKPEDE VLICIQQRPK RSTRREGKGE 420
NLAIGFDIYK VEENRQYRMH SLQHKAASSI YINSRSVFLR TDQPEGRYVI IPTTFEPGHT 480
GEFLLRVFTD VPSNCRELRL DEPPHTCWSS LCGYPQLVTQ VHVLGAAGLK DSPTGANSYV 540
IIKCEGDKVR SAVQKGTSTP EYNVKGIFYR KKLSQPITVQ VWNHRVLKDE FLGQVHLKAD 600
PDNLQALHTL HLRDRNSRQP SNLPGTVAVH ILSSTSLMAV 640 |
Gene Ontology | GO:0009986; C:cell surface; IDA:UniProtKB. GO:0005622; C:intracellular; IEA:InterPro. GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; TAS:ProtInc. GO:0006508; P:proteolysis; IEA:UniProtKB-KW. GO:0007165; P:signal transduction; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |