CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011599
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein SGT1 
Protein Synonyms/Alias
 Suppressor of G2 allele of SKP1 
Gene Name
 SGT1 
Gene Synonyms/Alias
 YOR057W; YOR29-08 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
32HLYDEILKGSPTNLTubiquitination[1, 2]
292SRLSDEGKNSDSATRubiquitination[2]
355AGADPDTKRAMMKSFubiquitination[2]
Reference
 [1] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Required for both entry into S phase and kinetochore function. Also involved in cyclic AMP (cAMP) pathway, possibly by participating in the assembly or the conformational activation of specific multiprotein complexes. 
Sequence Annotation
 DOMAIN 182 277 CS.
 DOMAIN 312 395 SGS.
 MOD_RES 168 168 Phosphoserine.
 MOD_RES 171 171 Phosphoserine.  
Keyword
 Cell cycle; Complete proteome; Phosphoprotein; Reference proteome; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 395 AA 
Protein Sequence
MPVEKDLKTA YKALYDEKEP LKALHLYDEI LKGSPTNLTA LIFKAACLEK LYFGFSDWHS 60
DATMENAKEL LDKALMTAEG RGDRSKIGLV NFRYFVHFFN IKDYELAQSY FKKAKNLGYV 120
DDTLPLWEDR LETKLNKKNK KQKDSTNKHT IKPVESIENR GDNNSSHSPI SPLKIETAPQ 180
ESPKFKIDWY QSSTSVTISL FTVNLPESKE QVNIYISPND RRTLSISYQV PKSGSEFQYN 240
AKLSHEVDPK AVSLKIFPKK LEITLSKIDS TQWKKLEEDI LTESSRLSDE GKNSDSATRL 300
LSAETASKER LSYPSSSKKK IDWSKLDIDE EADEEAGSAD SFFQKLYAGA DPDTKRAMMK 360
SFIESNGTAL STDWEDVSKG TVKTSPPEGM EPKHW 395 
Gene Ontology
 GO:0000151; C:ubiquitin ligase complex; IDA:SGD.
 GO:0051087; F:chaperone binding; IDA:SGD.
 GO:0030674; F:protein binding, bridging; IDA:SGD.
 GO:0019933; P:cAMP-mediated signaling; IPI:SGD.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051382; P:kinetochore assembly; IDA:SGD.
 GO:0016567; P:protein ubiquitination; TAS:SGD.
 GO:0051726; P:regulation of cell cycle; TAS:SGD. 
Interpro
 IPR007052; CS-like_domain.
 IPR017447; CS_domain.
 IPR008978; HSP20-like_chaperone.
 IPR007699; SGS.
 IPR011990; TPR-like_helical. 
Pfam
 PF04969; CS
 PF05002; SGS 
SMART
  
PROSITE
 PS51203; CS
 PS51048; SGS 
PRINTS