CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044587
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Calcium-dependent secretion activator 1 
Protein Synonyms/Alias
  
Gene Name
 Cadps 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
155KQQLQTVKDRFQAFLacetylation[1]
457THALPAVKVKLFTESubiquitination[2]
786KERFEEIKERLRVLLubiquitination[2]
843EVKTVIRKCLEQAALubiquitination[2]
1316LDSTLNSKTYETIRNubiquitination[2]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1356 AA 
Protein Sequence
MLDPSSSEEE SDEILEEERG KDVLGSAASG ARLSPSRTSE GSAGSAGMGG SGAGAGVGAG 60
GGGGSGASSG GGAGGLQPSS RAGGGRPSSP SPSVVSEKEK EELERLQKEE EERKKRLQLY 120
VFVMRCIAYP FNAKQPTDMA RRQQKISKQQ LQTVKDRFQA FLNGETQIVA DEAFMNAVQS 180
YYEVFLKSDR VARMVQSGGC SANDSREVFK KHIEKRVRSL PEIDGLSKET VLSSWMAKFD 240
AIYRGEEDPR KQQARMTASA ASELILSKEQ LYEMFQNILG IKKFEHQLLY NACQLDNPDE 300
QAAQIRRELD GRLQMADQIA RERKFPKFVS KEMENMYIEE LKSSVNLLMA NLESMPVSKG 360
GEFKLQKLKR SHNASIIDMG EESENQLSKS DVLLSFSLEV VIMEVQGLKS LAPNRIVYCT 420
MEVEGGEKLQ TDQAEASKPT WGTQGDFSTT HALPAVKVKL FTESTGVLAL EDKELGRVIL 480
HPTPNSPKQS EWHKMTVSKN CPDQDLKIKL AVRMDKPQNM KHSGYLWTIG KNVWKRWKKR 540
FFVLVQVSQY TFAMCSYREK KAEPQELLQL DGYTVDYTDP QPGLEGGRAF FNAVKEGDTV 600
IFASDDEQDR ILWVQAMYRA TGQSHKPVPP TQVQKLNAKG GNVPQLDAPI SQFYSSVKDA 660
DRAQKHGMDE FISSNPCNFD HASLFEMVQR LTLDHRLNDS YSCLGWFSPG QVFVLDEYCA 720
RNGVRGCHRH LCYLRDLLER AENGAMIDPT LLHYSFAFCA SHVHGNRPDG IGTVTVEEKE 780
RFEEIKERLR VLLENQITHF RYCFPFGRPE GALKATLSLL ERVLMKDIVT PVPQEEVKTV 840
IRKCLEQAAL VNYSRLSEYA KIEGHQKTAE NVGRLITPAK KLEDTIRLAE LVIEVLQQNE 900
EHHAEPHVDK GEAFAWWSDL MVEHAETFLS LFAVDMDAAL EVQPPDTWDS FPLFQLLNDF 960
LRTDYNLCNG KFHKHLQDLF APLVVRYVDL MESSIAQSIH RGFERESWEP VKSLTSNLPN 1020
VNLPNVNLPK VPNLPVNIPL GIPQMPTFSA PSWMAAIYDA DNGSGTSEDL FWKLDALQTF 1080
IRDLHWPEEE FGKHLEQRLK LMASDMIESC VKRTRIAFEV KLQKTSRSTD FRVPQSICTM 1140
FNVMVDAKAQ STKLCSMEMG QEHQYHSKID ELIEETVKEM ITLLVAKFVT ILEGVLAKLS 1200
RYDEGTLFSS FLSFTVKAAS KYVDVPKPGM DVADAYVTFV RHSQDVLRDK VNEEMYIERL 1260
FDQWYNSSMN IICTWLTDRM DLQLHIYQLK TLIRMVKKTY RDFRLQGVLD STLNSKTYET 1320
IRNRLTVEEA TASVSEGGGL QGISMKDSDE EDEEDD 1356 
Gene Ontology
 GO:0031410; C:cytoplasmic vesicle; IDA:MGI.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0050432; P:catecholamine secretion; IMP:MGI.
 GO:0016082; P:synaptic vesicle priming; IGI:MGI.
 GO:0016050; P:vesicle organization; IMP:MGI. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR010439; Ca-dep_secretion_activator.
 IPR014770; Munc13_1.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
 PF06292; DUF1041 
SMART
 SM00239; C2
 SM00233; PH 
PROSITE
 PS51258; MHD1
 PS50003; PH_DOMAIN 
PRINTS