CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007885
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Arrestin-related trafficking adapter 3 
Protein Synonyms/Alias
 Arrestin-like protein 2 
Gene Name
 ALY2 
Gene Synonyms/Alias
 ART3; YJL084C; J0934 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
392FKFAPLDKVTLHRIRubiquitination[1]
464KNGDLVNKEYEYQIFubiquitination[2]
616RQFNRNSKSHPSDNTubiquitination[2]
629NTIFNSAKLKSNIYQubiquitination[1, 2]
631IFNSAKLKSNIYQPEubiquitination[2]
773KRENRDVKSLSTPQRubiquitination[2]
903GINISKDKLNMEPLLubiquitination[2]
Reference
 [1] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli. 
Sequence Annotation
 MOD_RES 155 155 Phosphoserine.
 MOD_RES 162 162 Phosphoserine.
 MOD_RES 213 213 Phosphoserine.
 MOD_RES 586 586 Phosphoserine.
 MOD_RES 826 826 Phosphoserine.
 MOD_RES 838 838 Phosphoserine.
 MOD_RES 900 900 Phosphoserine.
 MOD_RES 1022 1022 Phosphoserine.
 MOD_RES 1023 1023 Phosphoserine.  
Keyword
 Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1046 AA 
Protein Sequence
MPMDQSISSP LFPMEKDIDI PLDATPLAQS SSLQLFIHLA EPVVFLQGFD PQKTEYPSVV 60
LRGCLVVRIL KPTKLKSISL SFKGYSRTEW PEGIPPKRQE FVEIKDIVDH TWALYPPTEQ 120
KSKKKMDASA PNESNNAANN FLTKESGASL YRTLSDNETI TSRKNSISGL SSLNLSPLGA 180
PGNSSVNVKD RESRQRSRSS SVTSSNGPSR NLSPINLLKR ATSPSVSHHN YKPTTTSIFS 240
DLLNNTFTHN DAASHHGHHI PTSSNHLAMT SNNFTSGSGG EFFVFQPGDY IYAFEELIPQ 300
AYPESIKADF GFVEYFLFAS IERPGAFKSN ISARQVVNIV RTQAHNSVEE SEPIIISRDW 360
ENQLYYDIVI ASKDIILDAF LPITFKFAPL DKVTLHRIRI YVTETMEYYC REKKVHRMEP 420
TKKFLLTEQK GPKLPNLPND ANLSKAKNMG NLLQDPKNGD LVNKEYEYQI FIPSRFNNHQ 480
QLHPDTSYEN IKANHWIKIC LRLSRVVDNK RKHYEISIDS PIHVLHRLCS HANTLLPSYD 540
GHPASFPKET DSSISSILES SDDNINLYHN SNIFFPKEVL SSPVLSPNVQ PLDILIPHLP 600
STSLTRNSRQ FNRNSKSHPS DNTIFNSAKL KSNIYQPESL QRELASPQAI PLSPITSPMS 660
NMEVPPPDFD FSSDFISDAA SGTTTTEVSS SESSILPRDP PSYKDTVLHD NNQKRRPNSK 720
HPTPPSLKAS HPNKNSDKNS SETLNKKESM SKIEENKHKR ETTPKKRENR DVKSLSTPQR 780
EESKDSTSTG NQSNEKNRKR VLSLSSSLHS SPNNSGFAHS ALGNLSNESL RSLNRRESVQ 840
DNLPSTIRHD NPFFTDLNQV LIEDELKNHD KNELNRHSTN TSSTPASARS SFDYSGINIS 900
KDKLNMEPLL SKTETLTNKV NEDSFLRPND SYVDLLEPSV DTTIDITAPY ARNSSAWHPL 960
QNDNDNNQFS PLLGSNENFL NAANAQNSAE SDHNNDIFTQ GSGLTESSKN SDSEERFISR 1020
LSSPEKVLIN TLDNESGLQS INESTL 1046 
Gene Ontology
 GO:0005769; C:early endosome; IDA:SGD.
 GO:0005770; C:late endosome; IDA:SGD.
 GO:2000397; P:positive regulation of ubiquitin-dependent endocytosis; IMP:SGD.
 GO:0032386; P:regulation of intracellular transport; IMP:SGD.
 GO:0070086; P:ubiquitin-dependent endocytosis; ISA:SGD. 
Interpro
 IPR011021; Arrestin-like_N.
 IPR011022; Arrestin_C-like.
 IPR014756; Ig_E-set. 
Pfam
 PF02752; Arrestin_C
 PF00339; Arrestin_N 
SMART
 SM01017; Arrestin_C 
PROSITE
  
PRINTS