CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028037
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 BIR-containing ubiquitin-conjugating enzyme 
Protein Synonyms/Alias
 Bruce 
Gene Name
 Bruce 
Gene Synonyms/Alias
 CG6303; Dmel_CG6303 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
4520VVSHHFEKMVRLAGDacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ligase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4876 AA 
Protein Sequence
MATEQHHQQR VLKQDGYLDL GDCNSAPSRP FEMRNVVYHP QLNVLLLFDN GSTVKVLDAN 60
SGVILQTYHL SSNGDSIVHG RYMPLQDKIL FWDGHNLGLR GDYNGVLLLD TILQAPIGQN 120
DDYIKLEIIL SEAIIFQNCI TELESEGLEC PCDISNELTQ KINQAQLKAK KGIKAQRWNT 180
ICLEVPYSSL KLVSNNMVIL LKRLERHIPV LAIASAINER LTDMMMGSRV PDFGWNFSNF 240
QRVLMHSEAV RRQTFEKWPH MDYKWALPDQ MAQAGFYHQP SSSGEDRAMC FTCSVCLVCW 300
EKTDEPWSEH ERHSPLCPFV KGEYTQNVPL SITYATNPAL PAPGLGFDII SNSDYANVLC 360
TSCSQTGELS VWSIERHLKL MHTFHVPTLL NYIFEESFEW ARVTAICVLP NARARTKVNY 420
VYSAANYGGS GSSNGAGCNS GLNAVSGGKF GSVNAQHITS TSTLRAGVVG SKIVLGVSVR 480
QSSGELALRM VVLNIVEVDR NSESSTSVSN DSGSVSSGGG QLMKSSSPMV NVSAENNATV 540
TQVNLESKDD DNKAMTPYEK FADGFDSNGF VSALMTYNKN NGVSQNTDDA SALYDFDLCT 600
LSQILDHNLE EPLSLMVGSS NTVNVSNIGM GNEINKLVVD VEISHQNNNN NNNNNNEASS 660
LGGNSSNNNN NIMINGGTNS SIDKMTAIEE IDCVVESWTS VKRMNALDGA SSGVNGVNHM 720
DQEVIEIAEI LPTTPKCNQL LVKLLRTKAP EAEGSKIIMA TVAKEEEEED EEQRTDESME 780
TDNNAEGNVA AQLLVFDYDD TEISNDYTLA MTFSRAKFPK QLCILPHFNS SPEHKDAGSI 840
CVVCADGTVE IYSLADFQGT MVIEEEGEHF ESVVYCRNLD RLCCCSRQGG LLFYSLSDGE 900
NDSGDELLEM DDDCSTTLTQ AADVSVTDGG RQLARTDLLG KTLLANESIC MDAGSEAAAI 960
PNSSSAAQGA HVQTSPSASS APSTNANLLA YKTADLTLED LKVFYALTQF DDKLTVYSAE 1020
VPSCWNDIGQ VQNQRKQSQN MRHGGDERDF TRTWRLHNDA TTWDEHIIEL NLAQPVSLGH 1080
IDLKFTVYQQ CSNPAAIQVT LLKQNNNGFG YRMKGPHSSY KPNVIDDNID LSYIANENPV 1140
LSEEYLLAHN AEVLAGPIEL SSCIDLCDQG GTATLTSPKL FKTRTRNFLL HIKTVSDPSK 1200
DGQNKTRGCD WLHEISISVR AVKSHSRISN GRMQRIAMLE SNVLLVQLLR IASDPASSSL 1260
AKNLSLDILN WICFIRLNRF RSPKSERLKD QINKQTAANI QDLLAQQFEC ISLAEKHIEQ 1320
LLRNCVIYSE RSTAHKCVKL LIMLTEGATN LPAEVQDHTT LDYSFKAAIA NTFPELPRAQ 1380
CGSVVRWYMM LTCATSTAES HNSISEQAIS LLKEIAAEID KRWDPHCALL CTRFGLYGYP 1440
FEPEIFDFDF PNVSRQGPGS SVANVIRSSP TILPVTGLDI KRLSSIDGVD FRTFPYLIRG 1500
KSISNQLRGL LEVVQLHFNC VQTSEATRID NIDSVGGNTG ANVIIEDVMM MPKQVVAKEK 1560
GEEMLNDLVN DVECLVEEMK VDENEKQEKV DYDAFGLVNG FKDKTLSSLN SVKQTLKEEV 1620
KKEKADIMDK LTIAKFLPKL SLLESYMQKK INEHISFDDF GKLDNWDGNT TPPFNLEVEA 1680
PIVCSEATSE SNMSQQATSA GGNILDDAAD SEKITESLNA NPCQPIAWHK LITPPPKQMI 1740
VIDRMHSGAR RFVVLDFGQH ILLTDLVIPS CDELTSLNID IWCFDEETDC TRLVQVNDIQ 1800
TKTLVLSDIQ PAPICRYLKL TIIGRIGMSA TKCKVPLGRF FGHPVVLEHD GYGDQLMKYI 1860
KHPTHSLQSQ IKSLNALYED VHCRYSLASS KLMDLLAPMR NSELSNVAHL QAFINKQREE 1920
ELSGLENNNK VVSLYDECML LQYQINVIRN VVLRLERALS PNSPTTTLLP GQSIPLTEDI 1980
LRAASRDKLR VLSLSLVEVL LHFSIEYGIK NILPVHQRFN AATAKALFNA LVVYGDAQLQ 2040
LATCSLLVRM CCFQPWWGDF LADTFCSLFS AQNCKAFPQD RIFFLLTYLG RRSIAMGACR 2100
SIVIDAVLKT LVKLLAPISP HYKFQSEQPS TSANAADRNA AMGTTSDLQL ITWLLLFLSV 2160
CLDDNERKDK SAARWDFMSC EGDFTKARPS ATPNIKQLRC FKKRIIQQNK YLAQPYADWG 2220
KKIYMIQNEH PGIFMELSTK SKGAGPTKST STGGKINMGS SGLCVGGPSS SSGNTSKSAA 2280
SSSSPKNQAV PGTDGERDSN FDKGLKSLRM DNIKVVIRGL FALLLEMDFD CNMDQFLLTC 2340
KVIARLVAAC RPSVQLCKIV TIAQLQQLVR LSVWNDQQHP WAVHAITCLL QDLLDADKQF 2400
RDNDVTPTND TPRTMEAAIQ ETRDLFSDYT STASSCTEAL FETLMPTARE FYQEAVKYNY 2460
LPSLIECDDT EFDEMLNDID MIERTKPVTK KESNALSKNT FNFFCKSISI ALDSRLDVGL 2520
ELHVETQLRR LTNRTSLDLY SSLPQVLTNE FVSPPPEAAP WPEYLTQLWS GTEYNGDNTY 2580
VMFKRVFDSI LAELHLEDTW VHLEQVLQMW LTLNCELSDK PYTSGITHSD VPKIPFGANA 2640
VQGLLLALAW HSDIKLRTWC LGFQCLFLAC NSLPIGDDAD CTRINEAIVN DENFEKVLLR 2700
FFSGYGMSSS IITNRCAGPT ICKHLHELLL WLHSKSETSG IPCKRRLKDI LLHVVLQLVQ 2760
PGGSISNQQG PIDAQNQLVR DLLMMPNDKG DLNIALKITE SVSFLVYNNI SNGERLQCQR 2820
GNENSPVGNN FSNLFANVLG SENPNKQNAA ICDNSLIINL LKLSSHMVLT EMPRQPSEVT 2880
IPEEEELSNQ SQTDETKAEQ LNTEGHRSKV PCIADWVLRH FPTMKRLFGT LSQCSTNTFT 2940
MMSSGCFFSP KSNMILDDPQ TIADAVFSLM ITLNDKASHP RLVVVPICRY LEETTIPRNA 3000
TLPRLPHSEP FLWYISKVLE VPAAVQTFTQ LGGIQIICHS LVRLNKTIIN MQPGLISLIM 3060
QHLTRNTRFK RNNHVAASSA CKKTTTGTGT TCPTSAQPPR SAAQYDGLIN FAPFSHIVSE 3120
NDATQSAEVL ISNPNNSHRR PRSPAWTYMF YPNETHVDLT ITLPTAILLK EVQLVPHTTS 3180
LASCPSAVAL ELSRDYGLGS IPVGAPMATT GLTCIRLKLA KAEVATSIVL RLYKPKDCGN 3240
VGLVQIAVLG QTIFGNRMHG LRSPSPFIDS LATCSSPVQT AVLAAMDADS MLEDDAFAKT 3300
SIGWVRILSR CFHVAALQPD SKLADLIAAY PAAYPGFLEA CCSLLNIMPM IPSLAQQHLE 3360
TILLKLSAYN HEISLQLLRT LLWHTTPQVF KLSSDSVCDL IYEVVTGSTE HLLDKLRVLI 3420
DWVMQLHDNY SKQARCNNPQ SGFVKVIASI LWKVHTQQQL PELPLLISSS LFETCFEWVS 3480
SLEHDEPLKS SFDSLLCALC FIKPELFNQL LVKLGVKLEP PARGQTDDSK VQSGSAWFRR 3540
EGSENLSVLL QRPTFLKTLA LACQSPAAVY QMLDSGLPKL LAHAIYEYCM HLMPGSEPVA 3600
SASTVPEDEP LANNQAAAAA DDEDSSLTDF DKAEANVVYN TPLLSSSNVP KVLDFFAECC 3660
AEGPMRDWLG TMQGSVFWKP LLQLLCNTHA AQFSKTLPKE QSFIRLERAT INFFTRVSAC 3720
HPGNQENLTS LLIGAIICKP LRFSHGVRPT ISGFTRQMVL QLLLENEHIT VSVRSQQPLQ 3780
RRDTLSAVLG GISSGASTSL PVAAVNNHPA RRSSAHHMLF TVTTSTTCQE IMQNCVSVFS 3840
NLVYQQPTDQ RAGETSASSS GVSSATAKSS ESKMEKSSFL NFNNVEAGSM EFLTVGAAVA 3900
AKDKRIKDAK NQAAMNKDKE TQTSSTNLAS NIFNVDEFLL QSANAVNGNQ LVIPEYSDIV 3960
LAGDATISQV LASLQNAGHS LSTPCISFDL VLQQRSDDTS EAKKTKAACT EPLPSPLQRF 4020
SSSGGLSLLA HYLPTVYPEH SGRKTTLVFS EKEKSPPLSD WVKLEPNDEI YEDLEDTLCE 4080
PAAKLATVSS VPQHSLAAFG LFLRLPAYSD VLLRDKMRAQ CLLRLVLGVT GDGDGNDIYS 4140
LSLAPSLPTL PFEVFRQLLD SVPLSTDDGV LLRRVVIEVG AMHLVLNCLG IFSHQSHNNR 4200
IGAPISEPSP SGTSSGSGTI GNGSGNGSVS GTKTNAPEEA TPSATSDDKS HMYWAKGTGF 4260
GTGSTTQSWN VEQALLRQKS EEEHVTVLLL VLASYINPGD CIPSEMCGED ILAYHDVRDV 4320
TGELPPIFQT LLQQSCLIPA LSSYLRNDSV LDITRHIPLY RAILKLLRAL SLSKMLVSLL 4380
QPSASGSGDS TPPIVELLTS MKTCVDTYAK RLKVNKKSNI KGQTHQLTFN IDDGDDEGLA 4440
LLIPDIHETS VLVQKTTDAD ALINMLHTNE DGSAQLEPQS KSIEQRYLEL MKKRQFDTFD 4500
MIVESDNNSF RFVVSHHFEK MVRLAGDRYH PSRVKRLAQE AVTLSTSLPL SFSSSVFVRC 4560
DTDRLDIMKV LITGPADTPY ANGCFEFDVF FPPDYPNQPM LINLETTGRH SVRFNPNLYN 4620
DGKVCLSVLN TWHGRPEEKW NAQTSSFLQV LVSIQSLILV PEPYFNEPGF ERSRGSPSGT 4680
NSSREYNSNI YQACVRWAML EQIRSPSQCF KDVIHKHFWL KREEICAQIE GWIEELGKPQ 4740
YTERASRTIS FNSMVLRRHY RHLREELSKL KPPRGLEDLD APFNPVATLP PMDVSAVAPS 4800
LAATNTVQAQ PDDAIVTDIT LLGENADECE ADGDAEGDGE VDDGFKGFPQ EEGLLTGEEE 4860
VVEILSDTEN ESSMWQ 4876 
Gene Ontology
 GO:0004842; F:ubiquitin-protein ligase activity; ISS:FlyBase.
 GO:0043066; P:negative regulation of apoptotic process; IDA:FlyBase.
 GO:0012501; P:programmed cell death; IGI:FlyBase.
 GO:0007286; P:spermatid development; IMP:FlyBase. 
Interpro
 IPR001370; BIR.
 IPR022103; DUF3643.
 IPR000608; UBQ-conjugat_E2.
 IPR016135; UBQ-conjugating_enzyme/RWD.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00653; BIR
 PF12356; DUF3643
 PF00179; UQ_con 
SMART
 SM00238; BIR 
PROSITE
 PS50143; BIR_REPEAT_2
 PS50127; UBIQUITIN_CONJUGAT_2 
PRINTS