UniProt Accession

 PARVA_HUMAN; Q9NVD7; Q96C85; Q9HA48 

Genbank Protein ID

 AF237771; AF325830; AK001655; AK022316; BC016713; BC014535 

Genbank Nucleotide ID

 AAG27173.1; AAK49911.1; BAA91815.1; BAB14009.1; AAH16713.1; AAH14535.1 

Protein Name

 Alpha-parvin 

Protein Synonyms/Alias

 Actopaxin; CH-ILKBP; Calponin-like integrin-linked kinase-binding protein; Matrix-remodeling-associated protein 2 

Gene Name

 PARVA 

Gene Synonyms/Alias

 MXRA2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
32	KDDSFLGKLGGTLAR	acetylation	[1]

Reference

 [1] Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
 Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G.
 J Cell Biol. 2011 Feb 21;192(4):615-29. [PMID: 21339330] 

Functional Description

 Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration. 

Sequence Annotation

 DOMAIN 95 201 CH 1.
 DOMAIN 262 369 CH 2.
 REGION 21 25 Interaction with ARHGAP31.
 MOD_RES 8 8 Phosphoserine (By similarity).
 MOD_RES 14 14 Phosphoserine.
 MOD_RES 19 19 Phosphoserine.
 MOD_RES 28 28 Phosphoserine.
 MOD_RES 62 62 Phosphoserine.  

Keyword

 3D-structure; Actin-binding; Alternative splicing; Angiogenesis; Cell adhesion; Cell junction; Cell membrane; Cell shape; Chemotaxis; Cilium biogenesis/degradation; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Membrane; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 372 AA 

Protein Sequence

Gene Ontology

 GO:0015629; C:actin cytoskeleton; IDA:HPA.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005925; C:focal adhesion; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
 GO:0070252; P:actin-mediated cell contraction; ISS:UniProtKB.
 GO:0034329; P:cell junction assembly; TAS:Reactome.
 GO:0060271; P:cilium morphogenesis; IMP:UniProtKB.
 GO:0007163; P:establishment or maintenance of cell polarity; ISS:UniProtKB.
 GO:0034113; P:heterotypic cell-cell adhesion; ISS:UniProtKB.
 GO:0003148; P:outflow tract septum morphogenesis; ISS:UniProtKB.
 GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
 GO:0071670; P:smooth muscle cell chemotaxis; ISS:UniProtKB.
 GO:0002040; P:sprouting angiogenesis; ISS:UniProtKB.
 GO:0034446; P:substrate adhesion-dependent cell spreading; IMP:UniProtKB. 

Interpro

 IPR001715; CH-domain. 

Pfam

 PF00307; CH 

SMART

 SM00033; CH 

PROSITE

 PS50021; CH 

PRINTS