CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036910
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Intersectin-2 
Protein Synonyms/Alias
  
Gene Name
 ITSN2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
89AMKLIKLKLQGQQLPubiquitination[1]
591QLLNERIKNMQFSNTubiquitination[1, 2]
608SGVSLLHKK******ubiquitination[2]
609GVSLLHKK*******ubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 609 AA 
Protein Sequence
MMAQFPTAMN GGPNMWAITS EERTKHDRQF DNLKPSGGYI TGDQARNFFL QSGLPAPVLA 60
EIWALSDLNK DGKMDQQEFS IAMKLIKLKL QGQQLPVVLP PIMKQPPMFS PLISARFGMG 120
SMPNLSIPQP LPPAAPITSL SSATSGTNLP PLMMPTPLVP SVSTSSLPNG TASLIQPLPI 180
PYSSSTLPHG SSYSLMMGGF GGASIQKAQS LIDLGSSRSW SSGSSAHSPA THRAPLSSPV 240
PNSSTSSTAS LSGNSPKTGT SEWAVPQPTR LKYRQKFNTL DKSMSGYLSG FQARNALLQS 300
NLSQTQLATI WTLADVDGDG QLKAEEFILA MHLTDMAKAG QPLPLTLPPE LVPPSFRGGK 360
QIDSINGTLP SYQKMQEEEP QKKLPVTFED KRKANYERGN MELEKRRQAL MEQQQREAER 420
KAQKEKEEWE RKQRELQEQE WKKQLELEKR LEKQRELERQ REEERRKDIE RREAAKQELE 480
RQRRLEWERI RRQELLNQKN REQEEIVRLN SKKKNLHLEL EALNGKHQQI SGRLQDVRLK 540
KQTQKTELEV LDKQCDLEIM EIKQLQQELQ EYQNKLIYLV PEKQLLNERI KNMQFSNTPD 600
SGVSLLHKK 609 
Gene Ontology
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0006897; P:endocytosis; IEA:InterPro. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR000261; EPS15_homology.
 IPR027029; Intersectin-2. 
Pfam
  
SMART
 SM00054; EFh
 SM00027; EH 
PROSITE
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS50031; EH 
PRINTS