CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022930
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Signal recognition particle subunit SRP68 
Protein Synonyms/Alias
 SRP68; Signal recognition particle 68 kDa protein 
Gene Name
 SRP68 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
220KCKTIYEKLASAFTEubiquitination[1]
302QAESEETKERLFESMubiquitination[1]
385QQPEDDSKRSPRPQDubiquitination[1]
473NSDAGAFKNSLKDLPubiquitination[1]
477GAFKNSLKDLPDVQEubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function. 
Sequence Annotation
 MOD_RES 48 48 Phosphoserine.
 MOD_RES 452 452 N6-acetyllysine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Ribonucleoprotein; RNA-binding; Signal recognition particle. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 627 AA 
Protein Sequence
MAAEKQVPGG GGGGGSGGGG GSGGGGSGGG RGAGGEENKE NERPSAGSKA NKEFGDSLSL 60
EILQIIKESQ QQHGLRHGDF QRYRGYCSRR QRRLRKTLNF KMGNRHKFTG KKVTEELLTD 120
NRYLLLVLMD AERAWSYAMQ LKQEANTEPR KRFHLLSRLR KAVKHAEELE RLCESNRVDA 180
KTKLEAQAYT AYLSGMLRFE HQEWKAAIEA FNKCKTIYEK LASAFTEEQA VLYNQRVEEI 240
SPNIRYCAYN IGDQSAKQAA TMSEVEWRGR TVPVKIDKVR IFLLGLADNE AAIVQAESEE 300
TKERLFESML SECRDAIQVV REELKPDQKQ RDYILEGEPG KVSNLQYLHS YLTYIKLSTA 360
IKRNENMAKG LQRALLQQQP EDDSKRSPRP QDLIRLYDII LQNLVELLQL PGLEEDKAFQ 420
KEIGLKTLVF KAYRCFFIAQ SYVLVKKWSE ALVLYDRVLK YANEVNSDAG AFKNSLKDLP 480
DVQELITQVR SEKCSLQAAA ILDANDAHQT ETSSSQVKDN KPLVERFETF CLDPSLVTKQ 540
ANLVHFPPGF QPIPCKPLFF DLALNHVAFP PLEDKLEQKT KSGLTGYIKG IFGFRS 596 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005783; C:endoplasmic reticulum; TAS:ProtInc.
 GO:0005730; C:nucleolus; TAS:ProtInc.
 GO:0005840; C:ribosome; TAS:ProtInc.
 GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IDA:UniProtKB.
 GO:0008312; F:7S RNA binding; IEA:InterPro.
 GO:0030942; F:endoplasmic reticulum signal peptide binding; IEA:InterPro.
 GO:0005047; F:signal recognition particle binding; IPI:UniProtKB.
 GO:0042493; P:response to drug; IDA:UniProtKB.
 GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome.
 GO:0006412; P:translation; TAS:Reactome. 
Interpro
 IPR026258; SRP68. 
Pfam
  
SMART
  
PROSITE
  
PRINTS