CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007863
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DNA polymerase delta small subunit 
Protein Synonyms/Alias
 Hydroxyurea-sensitive protein 2 
Gene Name
 POL31 
Gene Synonyms/Alias
 HUS2; HYS2; SDP5; YJR006W; J1427; YJR83.7 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
7*MDALLTKFNEDRSLacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 DNA polymerase delta (DNA polymerase III) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair. 
Sequence Annotation
 MOD_RES 20 20 Phosphoserine.  
Keyword
 Complete proteome; Direct protein sequencing; DNA replication; DNA-directed DNA polymerase; Nucleotidyltransferase; Nucleus; Phosphoprotein; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 487 AA 
Protein Sequence
MDALLTKFNE DRSLQDENLS QPRTRVRIVD DNLYNKSNPF QLCYKKRDYG SQYYHIYQYR 60
LKTFRERVLK ECDKRWDAGF TLNGQLVLKK DKVLDIQGNQ PCWCVGSIYC EMKYKPNVLD 120
EVINDTYGAP DLTKSYTDKE GGSDEIMLED ESGRVLLVGD FIRSTPFITG VVVGILGMEA 180
EAGTFQVLDI CYPTPLPQNP FPAPIATCPT RGKIALVSGL NLNNTSPDRL LRLEILREFL 240
MGRINNKIDD ISLIGRLLIC GNSVDFDIKS VNKDELMISL TEFSKFLHNI LPSISVDIMP 300
GTNDPSDKSL PQQPFHKSLF DKSLESYFNG SNKEILNLVT NPYEFSYNGV DVLAVSGKNI 360
NDICKYVIPS NDNGESENKV EEGESNDFKD DIEHRLDLME CTMKWQNIAP TAPDTLWCYP 420
YTDKDPFVLD KWPHVYIVAN QPYFGTRVVE IGGKNIKIIS VPEFSSTGMI ILLDLETLEA 480
ETVKIDI 487 
Gene Ontology
 GO:0005829; C:cytosol; IDA:SGD.
 GO:0043625; C:delta DNA polymerase complex; TAS:SGD.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0003887; F:DNA-directed DNA polymerase activity; IDA:SGD.
 GO:0006284; P:base-excision repair; TAS:SGD.
 GO:0043137; P:DNA replication, removal of RNA primer; IDA:SGD.
 GO:0006272; P:leading strand elongation; TAS:SGD.
 GO:0006298; P:mismatch repair; TAS:SGD.
 GO:0006289; P:nucleotide-excision repair; TAS:SGD.
 GO:0006301; P:postreplication repair; TAS:SGD.
 GO:0006278; P:RNA-dependent DNA replication; IDA:SGD. 
Interpro
 IPR007185; DNA_pol_alpha/epsilon_bsu.
 IPR024826; DNA_pol_delta/II_ssu. 
Pfam
 PF04042; DNA_pol_E_B 
SMART
  
PROSITE
  
PRINTS