CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027722
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Histone H2B 
Protein Synonyms/Alias
  
Gene Name
 TGGT1_022960, TgIb.2030, TGME49_009910, TGVEG_038620 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Toxoplasma gondii 
NCBI Taxa ID
 5811 
Lysine Modification
Position
Peptide
Type
References
4****MSGKGPAQKSQacetylation[1]
9SGKGPAQKSQAAKKTacetylation[1, 2]
14AQKSQAAKKTAGKSLacetylation[1, 2]
15QKSQAAKKTAGKSLGacetylation[1, 2]
19AAKKTAGKSLGPRYRacetylation[1, 2]
113HAVSEGTKAVTKYTTacetylation[1]
117EGTKAVTKYTTSGA*acetylation[1]
Reference
 [1] Protein intrinsic disorder in the acetylome of intracellular and extracellular Toxoplasma gondii.
 Xue B, Jeffers V, Sullivan WJ, Uversky VN.
 Mol Biosyst. 2013 Apr 5;9(4):645-57. [PMID: 23403842]
 [2] Lysine acetylation is widespread on proteins of diverse function and localization in the protozoan parasite Toxoplasma gondii.
 Jeffers V, Sullivan WJ Jr.
 Eukaryot Cell. 2012 Jun;11(6):735-42. [PMID: 22544907
Functional Description
 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). 
Sequence Annotation
  
Keyword
 Chromosome; Complete proteome; DNA-binding; Isopeptide bond; Nucleosome core; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 123 AA 
Protein Sequence
MSGKGPAQKS QAAKKTAGKS LGPRYRRRKR TESFALYIYK VLKQVHPETG VSKKSMSIMN 60
SFINDIFDRL ADEAVRLIRY NKKRTLSSRE IQTAVRLLLP GELSKHAVSE GTKAVTKYTT 120
SGA 123 
Gene Ontology
 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006334; P:nucleosome assembly; IEA:InterPro. 
Interpro
 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR000558; Histone_H2B. 
Pfam
 PF00125; Histone 
SMART
 SM00427; H2B 
PROSITE
 PS00357; HISTONE_H2B 
PRINTS
 PR00621; HISTONEH2B.