UniProt Accession

 CDC73_YEAST; Q06697; D6VZ54 

Genbank Protein ID

 U20162; BK006945 

Genbank Nucleotide ID

 AAB67500.1; DAA09720.1 

Protein Name

 Cell division control protein 73 

Protein Synonyms/Alias

 RNA polymerase-associated protein CDC73 

Gene Name

 CDC73 

Gene Synonyms/Alias

 YLR418C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
385	YFWHSLEKELISRGY	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 The PAF1 complex is a multifunctional complex. Involved in transcription initiation via genetic interactions with TATA- binding proteins. Involved in elongation. It regulates 3'-end formation of snR47 by modulating the recruitment or stable association of NRD1 and NAB3 with RNA polymerase II. Also has a role in transcription-coupled histone modification. Required for activation of RAD6 ubiquitin conjugate and the BRE1 ubiquitin ligase which ubiquitinate 'Lys-126' histone H2B. Activates the SET1 histone methyltransferase complex for methylation of 'Lys-4' of histone H3 and for methylation of 'Lys-73' of histone H3 by DOT1 and 'Lys-36' of histone H3 by SET2. 

Sequence Annotation

 MOD_RES 114 114 Phosphoserine.
 MOD_RES 150 150 Phosphoserine.  

Keyword

 3D-structure; Activator; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 393 AA 

Protein Sequence

Gene Ontology

 GO:0016593; C:Cdc73/Paf1 complex; IPI:SGD.
 GO:0035327; C:transcriptionally active chromatin; IDA:SGD.
 GO:0003682; F:chromatin binding; IDA:SGD.
 GO:0001089; F:TFIIF-class binding transcription factor activity; IMP:SGD.
 GO:0045910; P:negative regulation of DNA recombination; IMP:SGD.
 GO:2001255; P:positive regulation of histone H3-K36 trimethylation; IMP:SGD.
 GO:2001165; P:positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues; IMP:SGD.
 GO:2001209; P:positive regulation of transcription elongation from RNA polymerase I promoter; IDA:SGD.
 GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IMP:SGD.
 GO:0034402; P:recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex; IMP:SGD.
 GO:2001173; P:regulation of histone H2B conserved C-terminal lysine ubiquitination; IDA:SGD.
 GO:0090262; P:regulation of transcription-coupled nucleotide-excision repair; IGI:SGD.
 GO:0006362; P:transcription elongation from RNA polymerase I promoter; IMP:SGD.
 GO:0006368; P:transcription elongation from RNA polymerase II promoter; IGI:SGD. 

Interpro

 IPR007852; RNA_pol_access_fac_Cdc73. 

Pfam

 PF05179; CDC73 

SMART

  

PROSITE

  

PRINTS