UniProt Accession

 AROS_HUMAN; Q86WX3; B0QY96; Q5JZA1 

Genbank Protein ID

 CR456443; AL022312; CH471095; BC047711; BC037573 

Genbank Nucleotide ID

 CAG30329.1; CAQ08288.1; EAW60343.1; AAH47711.1; AAH37573.1 

Protein Name

 Active regulator of SIRT1 

Protein Synonyms/Alias

 40S ribosomal protein S19-binding protein 1; RPS19-binding protein 1; S19BP 

Gene Name

 RPS19BP1 

Gene Synonyms/Alias

 AROS 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
77	DHLRVNLKFLTRTRS	ubiquitination	[1]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity. 

Sequence Annotation

  

Keyword

 Complete proteome; Nucleus; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 136 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005730; C:nucleolus; ISS:HGNC.
 GO:0005654; C:nucleoplasm; ISS:HGNC. 

Interpro

 IPR023262; Active_regulator_of_SIRT1. 

Pfam

  

SMART

  

PROSITE

  

PRINTS

 PR02029; ACTREGSIRT1.