CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030688
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 cDNA FLJ51711, highly similar to T-complex protein 1 subunit epsilon 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
200VTSVEDYKALQKYEKubiquitination[1]
408EVRARQVKEMNPALGubiquitination[1]
454QMVRMILKIDDIRKPubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Chaperone; Cytoplasm; Nucleotide-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 466 AA 
Protein Sequence
MGLSMMDVDH QIAKLMVELS KSQDDEIGDG TTGVVVLAGA LLEEAEQLLD RGIHPIRIAD 60
GYEQAARVAI EHLDKISDSV LVDIKDTEPL IQTAKTTLGS KVVNSCHRQM AEIAVNAVLT 120
VADMERRDVD FELIKVEGKV GGRLEDTKLI KGVIVDKDFS HPQMPKKVED AKIAILTCPF 180
EPPKPKTKHK LDVTSVEDYK ALQKYEKEKF EEMIQQIKET GANLAICQWG FDDEANHLLL 240
QNNLPAVRWV GGPEIELIAI ATGGRIVPRF SELTAEKLGF AGLVQEISFG TTKDKMLVIE 300
QCKNSRAVTI FIRGGNKMII EEAKRSLHDA LCVIRNLIRD NRVVYGGGAA EISCALAVSQ 360
EADKCPTLEQ YAMRAFADAL EVIPMALSEN SGMNPIQTMT EVRARQVKEM NPALGIDCLH 420
KGTNDMKQQH VIETLIGKKQ QISLATQMVR MILKIDDIRK PGESEE 466 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0006457; P:protein folding; IEA:InterPro. 
Interpro
 IPR012718; Chap_CCT_epsi.
 IPR017998; Chaperone_TCP-1.
 IPR002194; Chaperonin_TCP-1_CS.
 IPR002423; Cpn60/TCP-1.
 IPR027409; GroEL-like_apical_dom.
 IPR027413; GROEL-like_equatorial.
 IPR027410; TCP-1-like_intermed. 
Pfam
 PF00118; Cpn60_TCP1 
SMART
  
PROSITE
 PS00995; TCP1_3 
PRINTS
 PR00304; TCOMPLEXTCP1.