CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034045
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Fascin 
Protein Synonyms/Alias
  
Gene Name
 Fscn1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
35AFRTHTGKYWTLTATacetylation[1]
121HGFIGCRKVTGTLDAacetylation[2]
121HGFIGCRKVTGTLDAsuccinylation[2]
121HGFIGCRKVTGTLDAubiquitination[3]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 144 AA 
Protein Sequence
MDLSANQDEE TDQETFQLEI DRDTRKCAFR THTGKYWTLT ATGGVQSTAS TKNASCYFDI 60
EWCDRRITLR ASNGKFVTAK KNGQLAASVE TAGDSELFLM KLINRPIIVF RGEHGFIGCR 120
KVTGTLDANR SSYDVFQLEF NDGA 144 
Gene Ontology
 GO:0030175; C:filopodium; IDA:MGI.
 GO:0071437; C:invadopodium; IEA:Compara.
 GO:0001725; C:stress fiber; IEA:Compara.
 GO:0051015; F:actin filament binding; IMP:MGI.
 GO:0051017; P:actin filament bundle assembly; IDA:MGI.
 GO:0048870; P:cell motility; IEA:Compara. 
Interpro
 IPR008999; Actin_cross-linking.
 IPR010431; Fascin.
 IPR022768; Fascin-domain. 
Pfam
 PF06268; Fascin 
SMART
  
PROSITE
  
PRINTS