UniProt Accession

 ARC1A_MOUSE; Q9R0Q6; Q3UL75 

Genbank Protein ID

 AB024984; AK076107; AK145663; BC001988 

Genbank Nucleotide ID

 BAA84685.1; BAC36187.1; BAE26575.1; AAH01988.1 

Protein Name

 Actin-related protein 2/3 complex subunit 1A 

Protein Synonyms/Alias

 SOP2-like protein; Sid 329 

Gene Name

 Arpc1a 

Gene Synonyms/Alias

 Sid329 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
87	SQKDGIWKPTLVILR	ubiquitination	[1]
179	YIKEVDEKPASTPWG	acetylation	[2]
179	YIKEVDEKPASTPWG	ubiquitination	[1]
235	VSVADASKSVQVSTL	ubiquitination	[1]
290	VSKLDVPKQSIQRNM	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. 

Sequence Annotation

 REPEAT 6 45 WD 1.
 REPEAT 50 89 WD 2.
 REPEAT 140 179 WD 3.
 REPEAT 202 241 WD 4.
 REPEAT 244 284 WD 5.
 REPEAT 322 365 WD 6.  

Keyword

 Actin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Reference proteome; Repeat; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 370 AA 

Protein Sequence

Gene Ontology

 GO:0005885; C:Arp2/3 protein complex; TAS:MGI.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro. 

Interpro

 IPR017383; ARPC2/3_su1.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS