CPLM-021883

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-021883

UniProt Accession

DNJA4_MOUSE; Q9JMC3; B2RW09; Q543S9; Q9CTD6; Q9CUD4

Genbank Protein ID

AB032401; AK003903; AK016666; AK046476; AK076175; AK141909; BC147484; BC147486

Genbank Nucleotide ID

BAA92775.1; BAB23067.1; BAB30367.2; BAC32747.1; BAC36232.1; BAE24880.1; AAI47485.1; AAI47487.1

Protein Name

DnaJ homolog subfamily A member 4

Protein Synonyms/Alias

MmDjA4

Gene Name

Dnaja4

Gene Synonyms/Alias

Created Date

July 27, 2013

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Lysine Modification

Position	Peptide	Type	References
32	AYRKLALKYHPDKNP	ubiquitination	[1]
313	NEGMPIYKAPLEKGV	ubiquitination	[1]

Reference

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]

Functional Description

Sequence Annotation

DOMAIN 4 70 J.
REPEAT 135 142 CXXCXGXG motif.
REPEAT 151 158 CXXCXGXG motif.
REPEAT 178 185 CXXCXGXG motif.
REPEAT 194 201 CXXCXGXG motif.
ZN_FING 122 206 CR-type.
METAL 135 135 Zinc 1 (By similarity).
METAL 138 138 Zinc 1 (By similarity).
METAL 151 151 Zinc 2 (By similarity).
METAL 154 154 Zinc 2 (By similarity).
METAL 178 178 Zinc 2 (By similarity).
METAL 181 181 Zinc 2 (By similarity).
METAL 194 194 Zinc 1 (By similarity).
METAL 197 197 Zinc 1 (By similarity).
MOD_RES 394 394 Cysteine methyl ester (By similarity).
LIPID 394 394 S-farnesyl cysteine (By similarity).

Keyword

Chaperone; Complete proteome; Lipoprotein; Membrane; Metal-binding; Methylation; Prenylation; Reference proteome; Repeat; Zinc; Zinc-finger.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

397 AA

Protein Sequence

MVKETQYYDI LGVKPSASPE EIKKAYRKLA LKYHPDKNPD EGEKFKLISQ AYEVLSDPKK 60
RDIYDQGGEQ AIKEGGSGSP SFSSPMDIFD MFFGGGGRMT RERRGKNVVH QLSVTLEDLY 120
NGITKKLALQ KNVICEKCEG IGGKKGSVEK CPLCKGRGMQ VHIQQIGPGM VQQIQTVCIE 180
CKGQGERINP KDRCENCSGA KVTREKKIIE VHVEKGMKDG QKILFHGEGD QEPELDPGDV 240
IIVLDQKDHS VFQRRGQDLI MKMKIQLSEA LCGFKKTIKT LDDRVLVISS KSGEVIKHGD 300
LKCIRNEGMP IYKAPLEKGV MIIQFLVVFP EKQWLSQEKL PQLEALLPPR QKVRITDDMD 360
QVELKEFNPN EQSWRQHREA YEEDDEEPRA GVQCQTA 397

Gene Ontology

GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:InterPro.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006457; P:protein folding; IEA:InterPro.
GO:0009408; P:response to heat; IEA:InterPro.

Interpro

IPR012724; DnaJ.
IPR002939; DnaJ_C.
IPR001623; DnaJ_domain.
IPR018253; DnaJ_domain_CS.
IPR008971; HSP40/DnaJ_pept-bd.
IPR001305; HSP_DnaJ_Cys-rich_dom.

Pfam

PF00226; DnaJ
PF01556; DnaJ_C
PF00684; DnaJ_CXXCXGXG

SMART

SM00271; DnaJ

PROSITE

PS00636; DNAJ_1
PS50076; DNAJ_2
PS51188; ZF_CR

PRINTS

PR00625; JDOMAIN.