CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040694
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 ARF GTPase-activating protein GIT2 
Protein Synonyms/Alias
  
Gene Name
 GIT2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
131DDDSVTAKDLSKQLHubiquitination[1]
135VTAKDLSKQLHSSVRubiquitination[1, 2]
365GSSLSGSKDNVELILubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 ANK repeat; Complete proteome; Metal-binding; Reference proteome; Repeat; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 708 AA 
Protein Sequence
MSKRLRSSEV CADCSGPDPS WASVNRGTFL CDECCSVHRS LGRHISQVRH LKHTPWPPTL 60
LQMVETLYNN GANSIWEHSL LDPASIMSGR RKANPQDKVH PNKAEFIRAK YQMLAFVHRL 120
PCRDDDSVTA KDLSKQLHSS VRTGNLETCL RLLSLGAQAN FFHPEKGNTP LHVASKAGQI 180
LQAELLAVYG ADPGTQDSSG KTPVDYARQG GHHELAERLV EIQYELTDRL AFYLCGRKPD 240
HKNGQHFIIP QMADSLDLSE LAKAAKKKLQ SLSNHLFEEL AMDVYDEVDR RETDAVWLAT 300
QNHSALVTET TVVPFLPVNP EYSSTRNQGR QKLARFNAHE FATLVIDILS DAKRRQQGSS 360
LSGSKDNVEL ILKTINNQHS VESQDNDQPD YDSVASDEDT DLETTASKTN RQKLQTLQSE 420
NSNLRKQATT NVYQVQTGSE YTDTSNHSSL KRRPSARGSR PMSMYETGSG QKPYLPMGEA 480
SRPEESRMRL QPFPAHIGRS ALVTSSSSLP SFPSTLSWSR DESARRASRL EKQNSTPESD 540
YDNTPNDMEP DGMGSSRKGR QRSMVWPGDG LVPDTAEPHV APSPTLPSTE DVIRKTEQIT 600
KNIQELLRAA QENKHDSYIP CSERIHVAVT EMAALFPKKP KSDMVRTSLR LLTSSAYRLQ 660
SECKKTLPGD PGSPTDVQLV TQQVIQCAYD IAKAAKQLVT ITTKENNN 708 
Gene Ontology
 GO:0008060; F:ARF GTPase activator activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR001164; ArfGAP.
 IPR022018; GIT1_C.
 IPR013724; GIT_SHD. 
Pfam
 PF12796; Ank_2
 PF01412; ArfGap
 PF12205; GIT1_C
 PF08518; GIT_SHD 
SMART
 SM00248; ANK
 SM00105; ArfGap
 SM00555; GIT 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS50115; ARFGAP 
PRINTS
 PR00405; REVINTRACTNG.