| Tag | Content |
|---|
| CPLM ID | CPLM-014502 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Glutamate receptor ionotropic, delta-2 |
Protein Synonyms/Alias | GluD2; GluR delta-2 subunit |
Gene Name | Grid2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 38 | AIFDESAKKDDEVFR | methylation | [1] | | 39 | IFDESAKKDDEVFRT | methylation | [1] |
|
Reference | [1] A method for the comprehensive proteomic analysis of membrane proteins. Wu CC, MacCoss MJ, Howell KE, Yates JR 3rd. Nat Biotechnol. 2003 May;21(5):532-8. [ PMID: 12692561] |
Functional Description | Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. |
Sequence Annotation | REGION 921 991 Interaction with AP4M1.
MOTIF 1005 1007 PDZ-binding (By similarity).
CARBOHYD 293 293 N-linked (GlcNAc...) (Potential).
CARBOHYD 426 426 N-linked (GlcNAc...) (Potential). |
Keyword | 3D-structure; Cell junction; Cell membrane; Complete proteome; Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel; Membrane; Postsynaptic cell membrane; Receptor; Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1007 AA |
Protein Sequence | MEVFPLLFFL SFWWSRTWDL ATSDSIIHIG AIFDESAKKD DEVFRTAVGD LNQNEEILQT 60
EKITFSVTFV DGNNPFQAVQ EACELMNQGI LALVSSIGCT SAGSLQSLAD AMHIPHLFIQ 120
RSTAGTPRSG CGLTRSNRND DYTLSVRPPV YLNEVILRVV TEYAWQKFII FYDSEYDIRG 180
IQEFLDKVSQ QGMDVALQKV ENNINKMITT LFDTMRIEEL NRYRDTLRRA ILVMNPATAK 240
SFISEVVETN LVAFDCHWII INEEINDVDV QELVRRSIGR LTIIRQTFPV PQNISQRCFR 300
GNHRISSTLC DPKDPFAQNM EISNLYIYDT VLLLANAFHK KLEDRKWHSM ASLSCIRKNS 360
KPWQGGRSML ETIKKGGVNG LTGDLEFGEN GGNPNVHFEI LGTNYGEELG RGVRKLGCWN 420
PVTGLNGSLT DKKLENNMRG VVLRVVTVLE EPFVMVSENV LGKPKKYQGF SIDVLDALSN 480
YLGFNYEIYV APDHKYGSPQ EDGTWNGLVG ELVFKRADIG ISALTITPDR ENVVDFTTRY 540
MDYSVGVLLR RAEKTVDMFA CLAPFDLSLW ACIAGTVLLV GLLVYLLNWL NPPRLQMGSM 600
TSTTLYNSMW FVYGSFVQQG GEVPYTTLAT RMMMGAWWLF ALIVISSYTA NLAAFLTITR 660
IESSIQSLQD LSKQTDIPYG TVLDSAVYQH VRMKGLNPFE RDSMYSQMWR MINRSNGSEN 720
NVLESQAGIQ KVKYGNYAFV WDAAVLEYVA INDPDCSFYT VGNTVADRGY GIALQHGSPY 780
RDVFSQRILE LQQSGDMDIL KHKWWPKNGQ CDLYSSVDAK QKGGALDIKS LAGVFCILAA 840
GIVLSCLIAV LETWWSRRKG SRVPSKEDDK EIDLEHLHRR VNSLCTDDDS PHKQFSTSSI 900
DLTPLDIDTL PTRQALEQIS DFRNTHITTT TFIPEQIQTL SRTLSAKAAS GFTFGSVPEH 960
RTGPFRHRAP NGGFFRSPIK TMSSIPYQPT PTLGLNLGND PDRGTSI 1007 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-KW. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0014069; C:postsynaptic density; IDA:RGD. GO:0045211; C:postsynaptic membrane; IDA:RGD. GO:0005234; F:extracellular-glutamate-gated ion channel activity; IEA:InterPro. GO:0004970; F:ionotropic glutamate receptor activity; IEA:InterPro. GO:0035235; P:ionotropic glutamate receptor signaling pathway; IEA:GOC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |