CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022327
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sphingomyelin phosphodiesterase 4 
Protein Synonyms/Alias
 Neutral sphingomyelinase 3; nSMase-3; nSMase3; Neutral sphingomyelinase III 
Gene Name
 SMPD4 
Gene Synonyms/Alias
 KIAA1418 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
106KLQAEDYKFDFPVSYubiquitination[1]
461RTDLVSPKHALMVFRacetylation[2]
461RTDLVSPKHALMVFRubiquitination[1]
621KTDEYLEKALEYLRQubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 
Functional Description
 Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. 
Sequence Annotation
 MOD_RES 130 130 Phosphoserine.
 MOD_RES 669 669 Phosphothreonine.  
Keyword
 Alternative splicing; Complete proteome; Endoplasmic reticulum; Golgi apparatus; Hydrolase; Magnesium; Membrane; Metal-binding; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 827 AA 
Protein Sequence
MAFPHLQQPS FLLASLKADS INKPFAQQCQ DLVKVIEDFP AKELHTIFPW LVESIFGSLD 60
GVLVGWNLRC LQGRVNPVEY SIVMEFLDPG GPMMKLVYKL QAEDYKFDFP VSYLPGPVKA 120
SIQECILPDS PLYHNKVQFT PTGGLGLNLA LNPFEYYIFF FALSLITQKP LPVSLHVRTS 180
DCAYFILVDR YLSWFLPTEG SVPPPLSSSP GGTSPSPPPR TPAIPFASYG LHHTSLLKRH 240
ISHQTSVNAD PASHEIWRSE TLLQVFVEMW LHHYSLEMYQ KMQSPHAKLE VLHYRLSVSS 300
ALYSPAQPSL QALHAYQESF TPTEEHVLVV RLLLKHLHAF ANSLKPEQAS PSAHSHATSP 360
LEEFKRAAVP RFVQQKLYLF LQHCFGHWPL DASFRAVLEM WLSYLQPWRY APDKQAPGSD 420
SQPRCVSEKW APFVQENLLM YTKLFVGFLN RALRTDLVSP KHALMVFRVA KVFAQPNLAE 480
MIQKGEQLFL EPELVIPHRQ HRLFTAPTFT GSFLSPWPPA VTDASFKVKS HVYSLEGQDC 540
KYTPMFGPEA RTLVLRLAQL ITQAKHTAKS ISDQCAESPA GHSFLSWLGF SSMDTNGSYT 600
ANDLDEMGQD SVRKTDEYLE KALEYLRQIF RLSEAQLRQF TLALGTTQDE NGKKQLPDCI 660
VGEDGLILTP LGRYQIINGL RRFEIEYQGD PELQPIRSYE IASLVRTLFR LSSAINHRFA 720
GQMAALCSRD DFLGSFCRYH LTEPGLASRH LLSPVGRRQV AGHTRGPRLS LRFLGSYRTL 780
VSLLLAFFVA SLFCVGPLPC TLLLTLGYVL YASAMTLLTE RGKLHQP 827 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0005794; C:Golgi apparatus; IDA:HGNC.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005802; C:trans-Golgi network; IDA:HGNC.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004767; F:sphingomyelin phosphodiesterase activity; TAS:Reactome.
 GO:0050290; F:sphingomyelin phosphodiesterase D activity; IDA:HGNC.
 GO:0071356; P:cellular response to tumor necrosis factor; IDA:BHF-UCL.
 GO:0046513; P:ceramide biosynthetic process; IDA:BHF-UCL.
 GO:0046475; P:glycerophospholipid catabolic process; IDA:BHF-UCL.
 GO:0006687; P:glycosphingolipid metabolic process; TAS:Reactome.
 GO:0006685; P:sphingomyelin catabolic process; IDA:HGNC. 
Interpro
 IPR024129; Sphingomy_SMPD4. 
Pfam
  
SMART
  
PROSITE
  
PRINTS