CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022624
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Inositol oxygenase 
Protein Synonyms/Alias
 Aldehyde reductase-like 6; Myo-inositol oxygenase; MI oxygenase; Renal-specific oxidoreductase 
Gene Name
 Miox 
Gene Synonyms/Alias
 Aldrl6; Rsor 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
2******MKVDVGPDPubiquitination[1]
23DVDPEMAKSKDSFRNubiquitination[1]
206YQMMKFNKFSLPSEAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
 REGION 85 88 Substrate binding.
 REGION 141 142 Substrate binding.
 REGION 220 221 Substrate binding.
 METAL 98 98 Iron 1.
 METAL 123 123 Iron 1.
 METAL 124 124 Iron 1.
 METAL 124 124 Iron 2.
 METAL 194 194 Iron 2.
 METAL 220 220 Iron 2.
 METAL 253 253 Iron 1.
 BINDING 29 29 Substrate.
 BINDING 127 127 Substrate.  
Keyword
 3D-structure; Complete proteome; Cytoplasm; Iron; Metal-binding; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 285 AA 
Protein Sequence
MKVDVGPDPS LVYRPDVDPE MAKSKDSFRN YTSGPLLDRV FTTYKLMHTH QTVDFVSRKR 60
IQYGSFSYKK MTIMEAVGML DDLVDESDPD VDFPNSFHAF QTAEGIRKAH PDKDWFHLVG 120
LLHDLGKIMA LWGEPQWAVV GDTFPVGCRP QASVVFCDST FQDNPDLQDP RYSTELGMYQ 180
PHCGLENVLM SWGHDEYLYQ MMKFNKFSLP SEAFYMIRFH SFYPWHTGGD YRQLCSQQDL 240
DMLPWVQEFN KFDLYTKCPD LPDVESLRPY YQGLIDKYCP GTLSW 285 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0016234; C:inclusion body; ISS:UniProtKB.
 GO:0004033; F:aldo-keto reductase (NADP) activity; IDA:UniProtKB.
 GO:0008199; F:ferric iron binding; ISS:UniProtKB.
 GO:0050113; F:inositol oxygenase activity; ISS:UniProtKB.
 GO:0050661; F:NADP binding; IEA:Compara.
 GO:0016651; F:oxidoreductase activity, acting on NAD(P)H; IDA:UniProtKB.
 GO:0019310; P:inositol catabolic process; ISS:UniProtKB. 
Interpro
 IPR018170; Aldo/ket_reductase_CS.
 IPR007828; Inositol_oxygenase. 
Pfam
 PF05153; DUF706 
SMART
  
PROSITE
 PS00063; ALDOKETO_REDUCTASE_3 
PRINTS