CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010441
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphatidylinositol-glycan-specific phospholipase D 
Protein Synonyms/Alias
 PI-G PLD; Glycoprotein phospholipase D; Glycosyl-phosphatidylinositol-specific phospholipase D; GPI-PLD; GPI-specific phospholipase D 
Gene Name
 GPLD1 
Gene Synonyms/Alias
 PIGPLD1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
764RVYVYNGKETTLGDMacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane. 
Sequence Annotation
 REPEAT 367 428 FG-GAP 1.
 REPEAT 436 497 FG-GAP 2.
 REPEAT 499 559 FG-GAP 3.
 REPEAT 563 623 FG-GAP 4.
 REPEAT 633 693 FG-GAP 5.
 REPEAT 704 770 FG-GAP 6.
 REPEAT 788 840 FG-GAP 7.
 CARBOHYD 94 94 N-linked (GlcNAc...).
 CARBOHYD 271 271 N-linked (GlcNAc...) (Potential).
 CARBOHYD 292 292 N-linked (GlcNAc...) (Potential).
 CARBOHYD 307 307 N-linked (GlcNAc...) (Potential).
 CARBOHYD 321 321 N-linked (GlcNAc...) (Potential).
 CARBOHYD 501 501 N-linked (GlcNAc...) (Potential).
 CARBOHYD 568 568 N-linked (GlcNAc...) (Potential).
 CARBOHYD 591 591 N-linked (GlcNAc...) (Potential).
 CARBOHYD 604 604 N-linked (GlcNAc...) (Potential).
 CARBOHYD 659 659 N-linked (GlcNAc...).  
Keyword
 Alternative splicing; Complete proteome; Direct protein sequencing; Glycoprotein; Hydrolase; Polymorphism; Reference proteome; Repeat; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 840 AA 
Protein Sequence
MSAFRLWPGL LIMLGSLCHR GSPCGLSTHV EIGHRALEFL QLHNGRVNYR ELLLEHQDAY 60
QAGIVFPDCF YPSICKGGKF HDVSESTHWT PFLNASVHYI RENYPLPWEK DTEKLVAFLF 120
GITSHMAADV SWHSLGLEQG FLRTMGAIDF HGSYSEAHSA GDFGGDVLSQ FEFNFNYLAR 180
RWYVPVKDLL GIYEKLYGRK VITENVIVDC SHIQFLEMYG EMLAVSKLYP TYSTKSPFLV 240
EQFQEYFLGG LDDMAFWSTN IYHLTSFMLE NGTSDCNLPE NPLFIACGGQ QNHTQGSKMQ 300
KNDFHRNLTT SLTESVDRNI NYTERGVFFS VNSWTPDSMS FIYKALERNI RTMFIGGSQL 360
SQKHVSSPLA SYFLSFPYAR LGWAMTSADL NQDGHGDLVV GAPGYSRPGH IHIGRVYLIY 420
GNDLGLPPVD LDLDKEAHRI LEGFQPSGRF GSALAVLDFN VDGVPDLAVG APSVGSEQLT 480
YKGAVYVYFG SKQGGMSSSP NITISCQDIY CNLGWTLLAA DVNGDSEPDL VIGSPFAPGG 540
GKQKGIVAAF YSGPSLSDKE KLNVEAANWT VRGEEDFSWF GYSLHGVTVD NRTLLLVGSP 600
TWKNASRLGH LLHIRDEKKS LGRVYGYFPP NGQSWFTISG DKAMGKLGTS LSSGHVLMNG 660
TLKQVLLVGA PTYDDVSKVA FLTVTLHQGG ATRMYALTSD AQPLLLSTFS GDRRFSRFGG 720
VLHLSDLDDD GLDEIIMAAP LRIADVTSGL IGGEDGRVYV YNGKETTLGD MTGKCKSWIT 780
PCPEEKAQYV LISPEASSRF GSSLITVRSK AKNQVVIAAG RSSLGARLSG ALHVYSLGSD 840 
Gene Ontology
 GO:0044444; C:cytoplasmic part; IDA:UniProtKB.
 GO:0005615; C:extracellular space; IDA:UniProtKB.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:UniProtKB.
 GO:0005578; C:proteinaceous extracellular matrix; ISS:UniProtKB.
 GO:0004621; F:glycosylphosphatidylinositol phospholipase D activity; IDA:UniProtKB.
 GO:0017080; F:sodium channel regulator activity; ISS:UniProtKB.
 GO:0002042; P:cell migration involved in sprouting angiogenesis; IMP:UniProtKB.
 GO:0071277; P:cellular response to calcium ion; IDA:UniProtKB.
 GO:0071397; P:cellular response to cholesterol; IMP:UniProtKB.
 GO:0035690; P:cellular response to drug; IDA:UniProtKB.
 GO:0071467; P:cellular response to pH; IDA:UniProtKB.
 GO:0071401; P:cellular response to triglyceride; IMP:UniProtKB.
 GO:0002062; P:chondrocyte differentiation; ISS:UniProtKB.
 GO:0002430; P:complement receptor mediated signaling pathway; IDA:UniProtKB.
 GO:0006507; P:GPI anchor release; IDA:UniProtKB.
 GO:0097241; P:hematopoietic stem cell migration to bone marrow; TAS:UniProtKB.
 GO:0008286; P:insulin receptor signaling pathway; IDA:UniProtKB.
 GO:0008285; P:negative regulation of cell proliferation; IDA:UniProtKB.
 GO:0010897; P:negative regulation of triglyceride catabolic process; ISS:UniProtKB.
 GO:0001503; P:ossification; ISS:UniProtKB.
 GO:0046470; P:phosphatidylcholine metabolic process; ISS:UniProtKB.
 GO:0010694; P:positive regulation of alkaline phosphatase activity; ISS:UniProtKB.
 GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.
 GO:0045919; P:positive regulation of cytolysis; IDA:UniProtKB.
 GO:0010595; P:positive regulation of endothelial cell migration; IMP:UniProtKB.
 GO:0010907; P:positive regulation of glucose metabolic process; ISS:UniProtKB.
 GO:0010983; P:positive regulation of high-density lipoprotein particle clearance; ISS:UniProtKB.
 GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; ISS:UniProtKB.
 GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IDA:UniProtKB.
 GO:0010867; P:positive regulation of triglyceride biosynthetic process; ISS:UniProtKB.
 GO:1900076; P:regulation of cellular response to insulin stimulus; IDA:UniProtKB.
 GO:0009749; P:response to glucose stimulus; IDA:UniProtKB.
 GO:0070633; P:transepithelial transport; ISS:UniProtKB. 
Interpro
 IPR013517; FG-GAP.
 IPR001028; Gprt_PLipase_D.
 IPR013519; Int_alpha_beta-p. 
Pfam
 PF01839; FG-GAP 
SMART
 SM00191; Int_alpha 
PROSITE
 PS51470; FG_GAP 
PRINTS
 PR00718; PHPHLIPASED.