| Tag | Content |
|---|
| CPLM ID | CPLM-016822 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sodium-coupled neutral amino acid transporter 2 |
Protein Synonyms/Alias | Amino acid transporter A2; Solute carrier family 38 member 2; System A amino acid transporter 2; System A transporter 1; System N amino acid transporter 2 |
Gene Name | Slc38a2 |
Gene Synonyms/Alias | Ata2; Kiaa1382; Sat2; Snat2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 33 | FNYSYPTKQAALKSH | ubiquitination | [1] | | 38 | PTKQAALKSHYADVD | ubiquitination | [1] | | 59 | LLESNLGKKKYETDF | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood- brain barrier and in the supply of maternal nutrients to the fetus through the placenta. |
Sequence Annotation | REGION 1 96 Regulates protein turnover upon amino
MOD_RES 12 12 Phosphoserine (By similarity).
MOD_RES 22 22 Phosphoserine (By similarity).
MOD_RES 41 41 Phosphotyrosine.
MOD_RES 55 55 Phosphoserine.
CARBOHYD 254 254 N-linked (GlcNAc...) (Potential).
CARBOHYD 258 258 N-linked (GlcNAc...) (Potential). |
Keyword | Amino-acid transport; Cell membrane; Complete proteome; Glycoprotein; Ion transport; Membrane; Phosphoprotein; Reference proteome; Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 504 AA |
Protein Sequence | MKKTEMGRFN ISPDEDSSSY SSNSDFNYSY PTKQAALKSH YADVDPENQN FLLESNLGKK 60
KYETDFHPGT TSFGMSVFNL SNAIVGSGIL GLSYAMANTG IALFIILLTF VSIFSLYSVH 120
LLLKTANEGG SLLYEQLGHK AYGLAGKLAA SGSITMQNIG AMSSYLFIVK YELPLVIKAL 180
MNIEDTNGLW YLNGDYLVLL VSLVLILPLS LLRNLGYLGY TSGLSLLCMI FFLIVVICKK 240
FQIPCPVEAA LVANETVNGT FTQAALALAF NSTADDACRP RYFIFNSQTV YAVPILTFSF 300
VCHPAVLPIY EELKSRSRRR MMNVSKISFF AMFLMYLLAA LFGYLTFYGH VESELLHTYS 360
EIVGTDILLL VVRLAVLVAV TLTVPVVIFP IRSSVTHLLC PTKEFSWLRH SIITVTILSF 420
TNLLVIFVPT IRDIFGFIGA SAAAMLIFIL PSAFYIKLVK KEPMRSVQKI GALCFLLSGI 480
VVMIGSMGLI VLDWVHDASA AGGH 504 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IDA:MGI. GO:0015171; F:amino acid transmembrane transporter activity; IDA:MGI. GO:0015293; F:symporter activity; IEA:UniProtKB-KW. GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |