CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042514
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Rho guanine nucleotide exchange factor 5 
Protein Synonyms/Alias
  
Gene Name
 ARHGEF5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
583LLLQNILKRTQPGSSubiquitination[1]
597SEEAEATKAHHALEQubiquitination[2]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 797 AA 
Protein Sequence
XVVVPTLKQH SHPPPLALGS GLHAPHKGPL PQASDPAVAR QHRPLPSTPD SSHHAQATPR 60
WRYNKPLPPT PDLPQPHLPP ISAPGSSRIY RPLPPLPIID PPTEPPPLPP KSRGRSRSTR 120
GGHMNSGGHA KTRPACQDWT VPLPASAGRT SWPPATARST ESFTSTSRSK SEVSPGMAFS 180
NMTNFLCPSS PTTPWTPELQ GPTSKDEAGV SEHPEAPARE PLRRTTPQQG ASGPGRSPVG 240
QARQPEKPSH LHLEKASSWP HRRDSGRPPG DSSGQAVAPS EGANKHKGWS RQGLRRPSIL 300
PEGSSDSRGP AVEKHPGPSD TVVFREKKPK EVMGGFSRRC SKLINSSQLL YQEYSDVVLN 360
KEIQSQQRLE SLSETPGPSS PRQPRKALVS SESYLQRLSM ASSGSLWQEI PVVRNSTVLL 420
SMTHEDQKLQ EVKFELIVSE ASYLRSLNIA VDHFQLSTSL RATLSNQEHQ WLFSRLQDVR 480
DVSATFLSDL EENFENNIFS FQVCDVVLNH APDFRRVYLP YVTNQTYQER TFQSLMNSNS 540
NFREVLEKLE SDPVCQRLSL KSFLILPFQR ITRLKLLLQN ILKRTQPGSS EEAEATKAHH 600
ALEQLIRDCN NNVQSMRRTE ELIYLSQKIE FECKIFPLIS QSRWLVKSGE LTALEFSASP 660
GLRRKLNTRP VHLHLFNDCL LLSRPRESEK LRWISALAMP REELDLLECY NSPQVQCLRA 720
YKPRENDELA LEKADVVMVT QQSSDGWLEG VRLSDGERGW FPVQQVEFIS NPEVRAQNLK 780
EAHRVKTAKL QLVEQQA 797 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. 
Interpro
 IPR000219; DH-domain.
 IPR001331; GDS_CDC24_CS.
 IPR001452; SH3_domain. 
Pfam
 PF00621; RhoGEF
 PF00018; SH3_1 
SMART
 SM00325; RhoGEF
 SM00326; SH3 
PROSITE
 PS00741; DH_1
 PS50010; DH_2
 PS50002; SH3 
PRINTS