CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029085
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 ETS translocation variant 2 
Protein Synonyms/Alias
  
Gene Name
 ETV2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
322KPGMNYEKLSRGLRYubiquitination[1, 2, 3]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; DNA-binding; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 370 AA 
Protein Sequence
MDLWNWDEAS PQEVPPGNKL AGLGRLPRLP QRVWGGCPGG ASADPNPLSP AEGAKLGFCF 60
PDLALQGDTP TATAETCWKG TSSSLASFPQ LDWGSALLHP EVPWGAEPDS QALPWSGDWT 120
DMACTAWDSW SGASQTLGPA PLGPGPIPAA GSEGAAGQNC VPVAGEATSW SRAQAAGSNT 180
SWDCSVGPDG DTYWGSGLGG EPRTDCTISW GGPAGPDCTT SWNPGLHAGG TTSLKRYQSS 240
ALTVCSEPSP QSDRASLARC PKTNHRGPIQ LWQFLLELLH DGARSSCIRW TGNSREFQLC 300
DPKEVARLWG ERKRKPGMNY EKLSRGLRYY YRRDIVRKSG GRKYTYRFGG RVPSLAYPDC 360
AGGGRGAETQ 370 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-KW.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro. 
Interpro
 IPR000418; Ets_dom.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF00178; Ets 
SMART
 SM00413; ETS 
PROSITE
 PS00345; ETS_DOMAIN_1
 PS00346; ETS_DOMAIN_2
 PS50061; ETS_DOMAIN_3 
PRINTS
 PR00454; ETSDOMAIN.