UniProt Accession

 ODP2_BOVIN; P11180 

Genbank Protein ID

  

Genbank Nucleotide ID

  

Protein Name

 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex 

Protein Synonyms/Alias

 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Pyruvate dehydrogenase complex component E2 

Gene Name

 DLAT 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Bos taurus (Bovine) 

NCBI Taxa ID

 9913 

Lysine Modification

Position	Peptide	Type	References
5	***VETDKATVGF**	acetylation	[1]

Reference

 [1] Primary structure around the lipoate-attachment site on the E2 component of bovine heart pyruvate dehydrogenase complex.
 Bradford AP, Howell S, Aitken A, James LA, Yeaman SJ.
 Biochem J. 1987 Aug 1;245(3):919-22. [PMID: 3117054] 

Functional Description

 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. 

Sequence Annotation

 MOD_RES 5 5 N6-lipoyllysine.  

Keyword

 Acyltransferase; Carbohydrate metabolism; Complete proteome; Direct protein sequencing; Glucose metabolism; Lipoyl; Mitochondrion; Reference proteome; Repeat; Transferase; Tricarboxylic acid cycle. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 10 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0004742; F:dihydrolipoyllysine-residue acetyltransferase activity; IEA:EC.
 GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
 GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW. 

Interpro

  

Pfam

  

SMART

  

PROSITE

 PS00189; LIPOYL 

PRINTS