CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-045454
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Pyruvate kinase 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
66EMLKEMIKSGMNVARacetylation[1]
89EYHAETIKNVRAATEacetylation[1]
115VAVALDTKGPEIRTGacetylation[1]
135GTAEVELKKGATLKIacetylation[1]
141LKKGATLKITLDNAYubiquitination[2]
166LDYKNICKVVEVGSKacetylation[1]
186GLISLQVKEKGADYLacetylation[1]
186GLISLQVKEKGADYLubiquitination[2]
188ISLQVKEKGADYLVTacetylation[1]
206NGGSLGSKKGVNLPGacetylation[1]
206NGGSLGSKKGVNLPGubiquitination[2]
207GGSLGSKKGVNLPGAubiquitination[2]
224DLPAVSEKDIQDLKFacetylation[1]
267EKVFLAQKMMIGRCNacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Glycolysis; Kinase; Magnesium; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 487 AA 
Protein Sequence
MPKPDSEAGT AFIQTQQLHA AMADTFLEHM CRLDIDSAPI TARNTGIICT IGPASRSVEM 60
LKEMIKSGMN VARLNFSHGT HEYHAETIKN VRAATESFAS DPILYRPVAV ALDTKGPEIR 120
TGLIKGSGTA EVELKKGATL KITLDNAYME KCDENILWLD YKNICKVVEV GSKIYVDDGL 180
ISLQVKEKGA DYLVTEVENG GSLGSKKGVN LPGAAVDLPA VSEKDIQDLK FGVEQDVDMV 240
FASFIRKAAD VHEVRKIPAE KVFLAQKMMI GRCNRAGKPV ICANQMLESM IKKPRPTRAE 300
GSDVANAVLD GADCIMLSGV TAKGDYPLEA VRMQHLIARE AEAAIYHLQL FEELRRLAPI 360
TSDPTEAAAV GAVEASFKCC SGAIIVLTKS GRSAHQVARY LPRAPIIAVT RNPQTARQAH 420
LYRGIFPVLC KDAVLDAWAE DVDLRVNLAM NVGKARGFFK KGDVVIVLTG WRPGSGFTNT 480
MRVVPVP 487 
Gene Ontology
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0030955; F:potassium ion binding; IEA:InterPro.
 GO:0004743; F:pyruvate kinase activity; IEA:EC.
 GO:0006096; P:glycolysis; IEA:UniProtKB-KW. 
Interpro
 IPR001697; Pyr_Knase.
 IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
 IPR011037; Pyrv_Knase-like_insert_dom.
 IPR015794; Pyrv_Knase_a/b.
 IPR015793; Pyrv_Knase_brl.
 IPR015795; Pyrv_Knase_C.
 IPR015806; Pyrv_Knase_insert_dom. 
Pfam
 PF00224; PK
 PF02887; PK_C 
SMART
  
PROSITE
  
PRINTS
 PR01050; PYRUVTKNASE.