CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008241
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Calcium-channel protein CCH1 
Protein Synonyms/Alias
  
Gene Name
 CCH1 
Gene Synonyms/Alias
 YGR217W; G8501 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
126RNVSPSTKSAKSSSQubiquitination[1]
460ISPGEETKYQRSSLSubiquitination[1]
472SLSTSLTKPYGAKENubiquitination[1]
641FLCPQYSKCVSNANPubiquitination[1]
1055NEDTRDFKQFLMRGTubiquitination[2]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Identification, analysis, and prediction of protein ubiquitination sites.
 Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM.
 Proteins. 2010 Feb 1;78(2):365-80. [PMID: 19722269] 
Functional Description
 Voltage-gated, high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones. Functions together with MID1 to ensure that adequate levels of Ca(2+) are supplied to PMR1 to sustain secretion and growth. Required for growth in low-calcium environments. 
Sequence Annotation
 DOMAIN 1787 1822 EF-hand.  
Keyword
 Calcium; Calcium channel; Calcium transport; Cell membrane; Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Stress response; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2039 AA 
Protein Sequence
MQGRKRTLTE PFEPNTNPFG DNAAVMTENV EDNSETDGNR LESKPQALVP PALNIVPPES 60
SIHSTEEKKG DEYNGNDKDS SLISNIFRTR VGRSSHENLS RPKLSLKTAS FGAAESSRRN 120
VSPSTKSAKS SSQYIDLNDE RLRRRSFSSY SRSSSRRVSN SPSSTDRPPR SAKVLSLIAA 180
DDMDDFEDLQ KGFKSAIDEE GLTWLPQLKS EKSRPVSDVG EDRGEGEQES IPDVHTPNVG 240
ASATPGSIHL TPEPAQNGSV SEGLEGSINN SRKKPSPKFF HHLSPQKEDK DQTEVIEYAE 300
DILDFETLQR KLESRPFVLY GHSLGVFSPT NPLRIKIARF LLHRRYSLLY NTLLTFYAIL 360
LAIRTYNPHN VVFLYRFSNW TDYFIFILSA CFTGNDIAKI IAFGFWDDSE MFKAYGREYK 420
SILQRSGIMK LYIYLREKYG RKLIDFIIPF RIISPGEETK YQRSSLSTSL TKPYGAKENQ 480
RPFGTPRAFA RSSWNRIDLV SSVSFWLGMF LSIKSYDTKT GIRIFKPLAI LRILRLVNVD 540
TGMPSILRGL KYGIPQLVNV SSMLVYFWIF FGILGVQIFQ GSFRRQCVWF NPEDPTDTYQ 600
YDMQFCGGYL DPVTKRKQNY IYEDGSEGSV SKGFLCPQYS KCVSNANPYN GRISFDNIVN 660
SMELVFVIMS ANTFTDLMYY TMDSDEMAAC LFFIVCIFVL TIWLLNLLIA VLVSSFEIAN 720
EEYKKKKFIY GSRKTGYVAR IVTGYWKYFK LKANQTKFPN WSQKGLAIYS HVEFIFVILI 780
ICDIGMRASV KVSTSANCNN ILLKTDRGIS IVLFIESLAR LVLYLPNMWK FLTKPSYVYD 840
FIISIITLVI SCLAVEGVLG HMYAWLSIFH ISRFYRVIIS FNLTKKLWKQ ILSNGVMIWN 900
LSSFYFFFTF LVAIIMAVYF EGVIPPEEMA DQPFGMYSLP NSFLSLFIIG STENWTDILY 960
ALQKHSPNIS STFFCSVFFI IWFLLSNSVI LNIFIALISE SMEVKEEEKR PQQIKHYLKF 1020
VYPQKIQEYT HASLVARIRK KFFGGHRNED TRDFKQFLMR GTAIMNIAQN MGELADEFKE 1080
PPSENLFKKG LSKLTIGVPS LKRLRMFANN PFYKNSDVVF TETNDINGRT YILELNEYED 1140
EKLDYLKKYP LFNYSYYFFS PQHRFRRFCQ RLVPPSTGKR TDGSRFFEDS TDLYNKRSYF 1200
HHIERDVFVF IFALATILLI VCSCYVTPLY RMHHKMGTWN WSSALDCAFI GAFSIEFIVK 1260
TVADGFIYSP NAYLRNPWNF IDFCVLISMW INLIAYLKNN GNLSRIFKGL TALRALRCLT 1320
ISNTARQTFN LVMFDGLNKI FEAGLISLSL LFPFTVWGLS IFKGRLGTCN DGSLGRADCY 1380
NEYSNSVFQW DIMSPRVYQQ PYLHLDSFAS AFSSLYQIIS LEGWVDLLEN MMNSSGIGTP 1440
ATVMGSAGNA LFLVLFNFLS MVFILNLFVS FIVNNQARTT GSAYFTIEEK AWLESQKLLS 1500
QAKPKAIPNL IELSRVRQFF YQLAVEKKNF YYASFLQVVL YLHIIMLLSR SYNPGNLIGY 1560
QGVYFMFSTS VFLIQEALHM CGEGPRLYFR QKWNSIRLSI IIIAFIMNAV AFHVPASHYW 1620
FHNIKGFFLL VIFLFIIPQN DTLTELLETA MASLPPILSL TYTWGVLFLV YAIALNQIFG 1680
LTRLGSNTTD NINFRTVIKS MIVLFRCSFG EGWNYIMADL TVSEPYCSSD DNSTYTDCGS 1740
ETYAYLLLMS WNIISMYIFV NMFVSLIIGN FSYVYRSGGS RSGINRSEIK KYIEAWSKFD 1800
TDGTGELELS YLPRIMHSFD GPLSFKIWEG RLTIKSLVEN YMEVNPDDPY DVKIDLIGLN 1860
KELNTIDKAK IIQRKLQYRR FVQSIHYTNA YNGCIRFSDL LLQIPLYTAY SARECLGIDQ 1920
YVHHLYILGK VDKYLENQRN FDVLEMVVTR WKFHCRMKRT IEPEWDVKDP TVSSHISNIN 1980
VNLEPAPGIL EREPIATPRM DYGVNNFMWS PRMNQDSTME PPEEPIDNND DSANDLIDR 2039 
Gene Ontology
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0005886; C:plasma membrane; IDA:SGD.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005245; F:voltage-gated calcium channel activity; ISS:SGD.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW. 
Interpro
 IPR002048; EF_hand_dom.
 IPR005821; Ion_trans_dom.
 IPR027359; K_channel_four-helix_dom. 
Pfam
 PF00520; Ion_trans 
SMART
  
PROSITE
 PS50222; EF_HAND_2 
PRINTS