CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008861
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 39 kDa FK506-binding nuclear protein 
Protein Synonyms/Alias
 Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase 
Gene Name
 FK506-bp1 
Gene Synonyms/Alias
 FKBP39; CG6226 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
10MFWGLNMKPERKYSQacetylation[1]
285GRLQSNNKTFDSLLKacetylation[1]
292KTFDSLLKGKPFKFAacetylation[1]
297LLKGKPFKFALGGGEacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Accelerates the folding of proteins. May function in a signal transduction cascade during early development. 
Sequence Annotation
 DOMAIN 269 357 PPIase FKBP-type.
 MOD_RES 92 92 Phosphoserine.
 MOD_RES 193 193 Phosphoserine.
 MOD_RES 197 197 Phosphoserine.  
Keyword
 Complete proteome; Isomerase; Nucleus; Phosphoprotein; Reference proteome; Rotamase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 357 AA 
Protein Sequence
MSMFWGLNMK PERKYSQTII KSFHISGVAL DKGQEAKLYL AAEKQEYIVA TVTKAIPQVA 60
LDLNFSKGDR IMFYTAGDAS VSLLGYLHDI DSEDDEDDDQ MTIENLLNSK AIKNSKKSED 120
DEDENESGEE DEEDTDDDSQ IIEEYESFLE NGEEEDDDDV DEDNEESGEE DEQDSDDSEA 180
EEEQPKAKVA KLSPGASAKK SGKEQNGVAK KEEAKQQQKK KEKPEAKKEQ PKAKEPAKQQ 240
PASKDPRTIT GGVKIVDQVV GKGEEAKQGK RVSVYYIGRL QSNNKTFDSL LKGKPFKFAL 300
GGGEVIKGWD VGVAGMKVGG KRVITCPPHM AYGARGAPPK IGPNSTLVFE VELKAVH 357 
Gene Ontology
 GO:0016020; C:membrane; IBA:RefGenome.
 GO:0005875; C:microtubule associated complex; IDA:FlyBase.
 GO:0005730; C:nucleolus; IBA:RefGenome.
 GO:0005528; F:FK506 binding; IDA:FlyBase.
 GO:0070594; F:juvenile hormone response element binding; IDA:FlyBase.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IBA:RefGenome.
 GO:0000412; P:histone peptidyl-prolyl isomerization; IBA:RefGenome.
 GO:0035626; P:juvenile hormone mediated signaling pathway; IMP:FlyBase.
 GO:0016242; P:negative regulation of macroautophagy; IMP:FlyBase.
 GO:0006457; P:protein folding; IEA:UniProtKB-KW. 
Interpro
 IPR026257; FK506_BP.
 IPR023566; PPIase_FKBP.
 IPR001179; PPIase_FKBP_dom. 
Pfam
 PF00254; FKBP_C 
SMART
  
PROSITE
 PS50059; FKBP_PPIASE 
PRINTS