CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022778
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Septin-6 
Protein Synonyms/Alias
  
Gene Name
 Sept6 
Gene Synonyms/Alias
 Kiaa0128 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
176TMKKLDSKVNIIPVIubiquitination[1]
387KKLEDKKKCLDEEMNubiquitination[1]
397DEEMNAFKQRKAAAEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. 
Sequence Annotation
 NP_BIND 49 56 GTP (By similarity).
 NP_BIND 185 193 GTP (By similarity).
 BINDING 104 104 GTP; via amide nitrogen (By similarity).
 BINDING 239 239 GTP; via amide nitrogen and carbonyl
 BINDING 254 254 GTP (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 367 367 N6-acetyllysine (By similarity).
 MOD_RES 416 416 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; Cell cycle; Cell division; Centromere; Chromosome; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; GTP-binding; Kinetochore; Nucleotide-binding; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 434 AA 
Protein Sequence
MAAADIARQV GEDCRTVPLA GHVGFDSLPD QLVNKSVSQG FCFNILCVGE TGLGKSTLMD 60
TLFNTKFEGE PATHTQPGVQ LQSNTYDLQE SNVGLKLTIV STVGFGDQIN KEDSYKPIVE 120
FIDAQFEAYL QEELKIRRVL HSYHDSRIHV CLYFIAPTGH SLKSLDLVTM KKLDSKVNII 180
PVIAKSDAIS KSELAKFKIK ITSELVSNGV QIYQFPTDDE SVSEINGTMN AHLPFAVVGS 240
TEEVKIGNKM MRARQYPWGT VQVENEAHCD FVKLREMLIR VNMEDLREQT HARHYELYRR 300
CKLEEMGFKD TDPDSKPFSL QETYEAKRNE FLGELQKKEE EMRQMFVQRV KEKEAELKEA 360
EKELHEKFDR LKKLHQEEKK KLEDKKKCLD EEMNAFKQRK AAAELLQSQG SQAGGSQTLK 420
RDKEKKNNPW LCIE 434 
Gene Ontology
 GO:0043679; C:axon terminus; IDA:MGI.
 GO:0032154; C:cleavage furrow; IEA:UniProtKB-SubCell.
 GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
 GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
 GO:0031105; C:septin complex; IEA:InterPro.
 GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
 GO:0008021; C:synaptic vesicle; IDA:MGI.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW. 
Interpro
 IPR000038; Cell_div_GTP-bd.
 IPR027417; P-loop_NTPase.
 IPR016491; Septin. 
Pfam
 PF00735; Septin 
SMART
  
PROSITE
  
PRINTS