UniProt Accession

 NSA2_HUMAN; O95478 

Genbank Protein ID

 AF372458; AJ012409; AF077615; BC005288 

Genbank Nucleotide ID

 AAK53761.1; CAA10008.1; AAG43048.1; AAH05288.1 

Protein Name

 Ribosome biogenesis protein NSA2 homolog 

Protein Synonyms/Alias

 Hairy cell leukemia protein 1; TGF-beta-inducible nuclear protein 1 

Gene Name

 NSA2 

Gene Synonyms/Alias

 TINP1; HUSSY-29 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
80	TKQKNDEKTPQGAVP	ubiquitination	[1]
100	REGQSRAKVLSNMIK	ubiquitination	[1]
109	LSNMIKQKRKEKAGK	ubiquitination	[1]
134	QGETEVLKVIRTGKR	ubiquitination	[2]
152	AWKRMVTKVCFVGDG	ubiquitination	[1]
179	RPMGLRFKKAHVTHP	ubiquitination	[1]
189	HVTHPELKATFCLPI	ubiquitination	[1, 3]
200	CLPILGVKKNPSSPL	ubiquitination	[3]
201	LPILGVKKNPSSPLY	ubiquitination	[1, 4]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity). 

Sequence Annotation

 MOD_RES 81 81 Phosphothreonine.  

Keyword

 Complete proteome; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Ribonucleoprotein; Ribosome biogenesis; rRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 260 AA 

Protein Sequence

Gene Ontology

 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0030529; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
 GO:0006364; P:rRNA processing; IEA:UniProtKB-KW. 

Interpro

 IPR022309; Ribosomal_S8e/biogenesis_NSA2. 

Pfam

 PF01201; Ribosomal_S8e 

SMART

  

PROSITE

  

PRINTS