UniProt Accession

 SSU72_MOUSE; Q9CY97; Q3UF99; Q91YL1; Q9DB51 

Genbank Protein ID

 AK005220; AK019168; AK148783; AL670236; AL670236; BC016544 

Genbank Nucleotide ID

 BAB23890.1; BAB31582.1; BAE28662.1; CAM18380.1; CAM18381.1; AAH16544.1 

Protein Name

 RNA polymerase II subunit A C-terminal domain phosphatase SSU72 

Protein Synonyms/Alias

 CTD phosphatase SSU72 

Gene Name

 Ssu72 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
43	FGTGTHVKLPGPAPD	ubiquitination	[1]
73	NDLLRKDKELYTQNG	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK. 

Sequence Annotation

  

Keyword

 Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Hydrolase; mRNA processing; Nucleus; Protein phosphatase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 194 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0008420; F:CTD phosphatase activity; ISS:UniProtKB.
 GO:0070940; P:dephosphorylation of RNA polymerase II C-terminal domain; ISS:UniProtKB.
 GO:0006378; P:mRNA polyadenylation; ISS:UniProtKB. 

Interpro

 IPR006811; RNA_pol_II_suA. 

Pfam

 PF04722; Ssu72 

SMART

  

PROSITE

  

PRINTS