UniProt Accession

 RINI_MOUSE; Q91VI7; Q924P4 

Genbank Protein ID

 AF071546; AK133822; AK141351; AK147059; BC010331 

Genbank Nucleotide ID

 AAK68859.1; BAE21862.1; BAE24659.1; BAE27643.1; AAH10331.1 

Protein Name

 Ribonuclease inhibitor 

Protein Synonyms/Alias

 Ribonuclease/angiogenin inhibitor 1 

Gene Name

 Rnh1 

Gene Synonyms/Alias

 Rnh 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
41	GLTEVRCKDISSAVQ	ubiquitination	[1]
81	GLQNPTCKIQKLSLQ	ubiquitination	[1]
84	NPTCKIQKLSLQNCG	ubiquitination	[1]
168	LRVKADFKELVLSNN	acetylation	[2]
190	RILCQGLKDSACQLE	acetylation	[2]
200	ACQLESLKLENCGIT	acetylation	[2]
200	ACQLESLKLENCGIT	ubiquitination	[1]
221	LCDVVASKASLQELD	ubiquitination	[1]
282	LRAKQSLKELSLASN	ubiquitination	[1]
292	SLASNELKDEGARLL	ubiquitination	[1]
418	LQLLESLKQPSCTLQ	acetylation	[3]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

 Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis (By similarity). 

Sequence Annotation

 REPEAT 15 43 LRR 1.
 REPEAT 44 71 LRR 2.
 REPEAT 72 100 LRR 3.
 REPEAT 101 128 LRR 4.
 REPEAT 129 157 LRR 5.
 REPEAT 158 185 LRR 6.
 REPEAT 186 214 LRR 7.
 REPEAT 215 242 LRR 8.
 REPEAT 243 271 LRR 9.
 REPEAT 272 299 LRR 10.
 REPEAT 300 328 LRR 11.
 REPEAT 329 356 LRR 12.
 REPEAT 357 385 LRR 13.
 REPEAT 386 413 LRR 14.
 REPEAT 414 442 LRR 15.
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 86 86 Phosphoserine (By similarity).  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Leucine-rich repeat; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 456 AA 

Protein Sequence

Gene Ontology

 GO:0032311; C:angiogenin-PRI complex; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0008428; F:ribonuclease inhibitor activity; IEA:Compara.
 GO:0045765; P:regulation of angiogenesis; IEA:Compara. 

Interpro

 IPR003590; Leu-rich_rpt_RNase_inh_sub-typ. 

Pfam

  

SMART

 SM00368; LRR_RI 

PROSITE

  

PRINTS