CPLM-003824

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-003824

UniProt Accession

Genbank Protein ID

J03225; M58650; M58644; M58645; M58646; M58647; M58648; M58649; M59499; M59493; M59494; M59495; M59496; M59497; M59498; AF021834; AY263365; AC007319; CH471058; CH471058; BC015514

Genbank Nucleotide ID

AAA52022.1; AAA59480.1; AAA59480.1; AAA59480.1; AAA59480.1; AAA59480.1; AAA59480.1; AAA59480.1; AAA59526.1; AAA59526.1; AAA59526.1; AAA59526.1; AAA59526.1; AAA59526.1; AAA59526.1; AAD01700.1; AAO89075.1; AAY14807.1; EAX10921.1; EAX10922.1; AAH15514.1

Protein Name

Tissue factor pathway inhibitor

Protein Synonyms/Alias

TFPI; Extrinsic pathway inhibitor; EPI; Lipoprotein-associated coagulation inhibitor; LACI

Gene Name

TFPI

Gene Synonyms/Alias

LACI; TFPI1

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
268	QECLRACKKGFIQRI	acetylation	[1]
269	ECLRACKKGFIQRIS	acetylation	[1]

Reference

[1] Regulation of cellular metabolism by protein lysine acetylation.
Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]

Functional Description

Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.

Sequence Annotation

DOMAIN 54 104 BPTI/Kunitz inhibitor 1.
DOMAIN 125 175 BPTI/Kunitz inhibitor 2.
DOMAIN 217 267 BPTI/Kunitz inhibitor 3.
CARBOHYD 42 42 O-linked (GalNAc...); partial.
CARBOHYD 145 145 N-linked (GlcNAc...).
CARBOHYD 195 195 N-linked (GlcNAc...).
CARBOHYD 202 202 O-linked (GalNAc...); partial.
CARBOHYD 203 203 O-linked (GalNAc...).
DISULFID 54 104 By similarity.
DISULFID 63 87 By similarity.
DISULFID 79 100 By similarity.
DISULFID 125 175
DISULFID 134 158
DISULFID 150 171
DISULFID 217 267
DISULFID 226 250
DISULFID 242 263

Keyword

3D-structure; Alternative splicing; Blood coagulation; Complete proteome; Direct protein sequencing; Disulfide bond; Endoplasmic reticulum; Glycoprotein; GPI-anchor; Hemostasis; Lipoprotein; Membrane; Microsome; Polymorphism; Protease inhibitor; Reference proteome; Repeat; Secreted; Serine protease inhibitor; Signal.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

304 AA

Protein Sequence

MIYTMKKVHA LWASVCLLLN LAPAPLNADS EEDEEHTIIT DTELPPLKLM HSFCAFKADD 60
GPCKAIMKRF FFNIFTRQCE EFIYGGCEGN QNRFESLEEC KKMCTRDNAN RIIKTTLQQE 120
KPDFCFLEED PGICRGYITR YFYNNQTKQC ERFKYGGCLG NMNNFETLEE CKNICEDGPN 180
GFQVDNYGTQ LNAVNNSLTP QSTKVPSLFE FHGPSWCLTP ADRGLCRANE NRFYYNSVIG 240
KCRPFKYSGC GGNENNFTSK QECLRACKKG FIQRISKGGL IKTKRKRKKQ RVKIAYEEIF 300
VKNM 304

Gene Ontology

GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW.
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
GO:0005615; C:extracellular space; IDA:BHF-UCL.
GO:0031090; C:organelle membrane; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0004866; F:endopeptidase inhibitor activity; TAS:ProtInc.
GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
GO:0007598; P:blood coagulation, extrinsic pathway; TAS:Reactome.

Interpro

IPR002223; Prot_inh_Kunz-m.
IPR008296; Prot_inhib_I2_TFPI.
IPR020901; Prtase_inh_Kunz-CS.

Pfam

PF00014; Kunitz_BPTI

SMART

SM00131; KU

PROSITE

PS00280; BPTI_KUNITZ_1
PS50279; BPTI_KUNITZ_2

PRINTS