UniProt Accession

 AROG_YEAST; P32449; D6VQP5 

Genbank Protein ID

 X61107; L20296; Z36118; BK006936 

Genbank Nucleotide ID

 CAA43419.1; AAA65607.1; CAA85212.1; DAA07365.1 

Protein Name

 Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited 

Protein Synonyms/Alias

 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase; DAHP synthase; Phospho-2-keto-3-deoxyheptonate aldolase 

Gene Name

 ARO4 

Gene Synonyms/Alias

 YBR249C; YBR1701 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
65	AIDIITGKDDRVLVI	acetylation	[1]
120	PRTTVGWKGLINDPD	ubiquitination	[2]
136	NNTFNINKGLQSARQ	ubiquitination	[2]
287	YSHGNSNKDFRNQPK	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP). 

Sequence Annotation

  

Keyword

 3D-structure; Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Complete proteome; Reference proteome; Stress response; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 370 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IDA:SGD.
 GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
 GO:0009423; P:chorismate biosynthetic process; TAS:SGD.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW. 

Interpro

 IPR013785; Aldolase_TIM.
 IPR006218; DAHP1/KDSA.
 IPR006219; DHAP_synth_1. 

Pfam

 PF00793; DAHP_synth_1 

SMART

  

PROSITE

  

PRINTS