CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014827
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein DEK 
Protein Synonyms/Alias
  
Gene Name
 Dek 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
59KSLIVEGKREKRKVEacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Involved in chromatin organization (By similarity). 
Sequence Annotation
 DOMAIN 149 183 SAP.
 DNA_BIND 340 354 By similarity.
 DNA_BIND 370 374 By similarity.
 MOTIF 207 223 Nuclear localization signal (Potential).
 MOD_RES 14 14 Phosphothreonine (By similarity).
 MOD_RES 20 20 Phosphoserine (By similarity).
 MOD_RES 33 33 Phosphoserine (By similarity).
 MOD_RES 53 53 Phosphoserine (By similarity).
 MOD_RES 161 161 Phosphoserine (By similarity).
 MOD_RES 203 203 Phosphoserine (By similarity).
 MOD_RES 206 206 Phosphoserine (By similarity).
 MOD_RES 212 212 Phosphoserine (By similarity).
 MOD_RES 229 229 Phosphoserine (By similarity).
 MOD_RES 232 232 Phosphoserine (By similarity).
 MOD_RES 233 233 Phosphoserine (By similarity).
 MOD_RES 234 234 Phosphoserine (By similarity).
 MOD_RES 245 245 Phosphoserine (By similarity).
 MOD_RES 246 246 Phosphoserine (By similarity).
 MOD_RES 253 253 Phosphoserine (By similarity).
 MOD_RES 290 290 Phosphoserine (By similarity).
 MOD_RES 291 291 Phosphoserine (By similarity).
 MOD_RES 292 292 Phosphothreonine (By similarity).
 MOD_RES 293 293 Phosphothreonine (By similarity).
 MOD_RES 299 299 Phosphoserine (By similarity).
 MOD_RES 304 304 Phosphoserine (By similarity).
 MOD_RES 306 306 Phosphoserine (By similarity).
 MOD_RES 309 309 Phosphoserine (By similarity).
 MOD_RES 310 310 Phosphoserine (By similarity).  
Keyword
 Chromatin regulator; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 378 AA 
Protein Sequence
MSAAAAPAAE GEDTPTPPAS EKEPEMPGPR EESEEEEEED DDDEDEEEEK EKSLIVEGKR 60
EKRKVERLTM QVSSLQREPF TIAQGKGQKL CEIERIHFFL SKKKTDELRN LHKLLYNRPG 120
TVSSLKKNVG QFSGFPFEKG STQYKKKEEM LKKYRNAMLK SICEVLDLER SGVNSELVKR 180
ILNFLMHPKP SGKPLPKSKK SSSKGSKKER NSSGTTRKSK QTKCPEILSD ESSSDEDEKK 240
NKDESSEDEE KESEEEQPPK KTSKKEKAKQ KATTKSKKSV KSANVKKADS STTKKNQNSS 300
KKESGSEDSS DDEPLIKKLK KPPTDEELKE TVKKLLADAN LEEVTMKQIC KEVYENYPAY 360
DLTERKDFIK TTVKELIS 378 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
 GO:2001032; P:regulation of double-strand break repair via nonhomologous end joining; IEA:Compara. 
Interpro
 IPR014876; DEK_C.
 IPR009057; Homeodomain-like.
 IPR003034; SAP_dom. 
Pfam
 PF08766; DEK_C
 PF02037; SAP 
SMART
 SM00513; SAP 
PROSITE
 PS50800; SAP 
PRINTS