| Tag | Content |
|---|
| CPLM ID | CPLM-001408 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Signal transducing adapter molecule 2 |
Protein Synonyms/Alias | STAM-2; Hrs-binding protein |
Gene Name | Stam2 |
Gene Synonyms/Alias | Hbp |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 134 | SLISATIKSMKEEGV | ubiquitination | [1] | | 156 | QTVAAAAKNGTSLNK | ubiquitination | [1] | | 182 | ELSLQEQKQQYTETK | ubiquitination | [1] | | 189 | KQQYTETKALYPPAE | ubiquitination | [1] | | 202 | AESQLNNKAARRVRA | ubiquitination | [1] | | 284 | DDVEEIKKSEPEPVY | ubiquitination | [1] | | 343 | KLEEIDRKHSELSEL | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). |
Sequence Annotation | DOMAIN 16 144 VHS.
REPEAT 165 184 UIM.
DOMAIN 202 261 SH3.
DOMAIN 360 377 ITAM.
REGION 219 220 Interaction with USP8.
REGION 334 368 Interaction with HGS.
MOTIF 54 67 PxVxL motif.
MOD_RES 374 374 Phosphotyrosine. |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Endosome; Membrane; Phosphoprotein; Protein transport; Reference proteome; SH3 domain; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 523 AA |
Protein Sequence | MPLFTANPFE QDVEKATNEY NTTEDWSLIM DICDRVGSTP SGAKDCLKAI MKRVNHKVPH 60
VALQALTLLG ACVANCGKIF HLEVCSRDFA TEVRSVIKNK AHPKVCEKLK SLMVEWSEEF 120
QKDPQFSLIS ATIKSMKEEG VTFPSAGSQT VAAAAKNGTS LNKNKEDEDI AKAIELSLQE 180
QKQQYTETKA LYPPAESQLN NKAARRVRAL YDFEAVEDNE LTFKHGELIT VLDDSDANWW 240
QGENHRGTGL FPSNFVTTDL STEVETATVD KLNVIDDDVE EIKKSEPEPV YIDEGKMDRA 300
LQILQSIDPK ESKPDSQDLL DLEDVCQQMG PMIDEKLEEI DRKHSELSEL NVKVLEALDL 360
YNKLVNEAPV YSVYSKLHPA HYPPAAAGVP VQTYPVQSHG GNYLGHGIHQ VSVAQNYNLG 420
PDPMGSLRSL PPNMNSVTAH TVQPPYLSTG QDTVSNPSYM NQSSRLQAAA GTAAYTQPVG 480
MSTDVSSFQN TASGLPQLAG FPVAVPAPVA AQPQASYHQQ PLL 523 |
Gene Ontology | GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:Compara. GO:0006886; P:intracellular protein transport; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |