| Tag | Content |
|---|
| CPLM ID | CPLM-000262 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Chromodomain-helicase-DNA-binding protein 1 |
Protein Synonyms/Alias | CHD-1; ATP-dependent helicase CHD1 |
Gene Name | CHD1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 401 | IIAHSNQKSAAGYPD | ubiquitination | [1] | | 1062 | LEEEERQKELEEIYM | ubiquitination | [1] | | 1160 | RDAELVDKSETDLRR | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells. |
Sequence Annotation | DOMAIN 272 364 Chromo 1.
DOMAIN 389 452 Chromo 2.
DOMAIN 493 663 Helicase ATP-binding.
DOMAIN 792 943 Helicase C-terminal.
REPEAT 1628 1632 1.
REPEAT 1634 1638 2.
REPEAT 1640 1644 3.
NP_BIND 506 513 ATP (Potential).
REGION 1628 1644 3 X 5 AA repeats of H-S-D-H-R.
MOTIF 614 617 DEAH box.
MOD_RES 5 5 Phosphoserine (By similarity).
MOD_RES 215 215 Phosphoserine.
MOD_RES 216 216 Phosphoserine.
MOD_RES 237 237 Phosphothreonine.
MOD_RES 241 241 Phosphoserine.
MOD_RES 250 250 Phosphothreonine.
MOD_RES 252 252 Phosphoserine.
MOD_RES 1025 1025 Phosphoserine.
MOD_RES 1040 1040 Phosphoserine.
MOD_RES 1081 1081 Phosphoserine.
MOD_RES 1096 1096 Phosphoserine.
MOD_RES 1098 1098 Phosphoserine.
MOD_RES 1100 1100 Phosphoserine.
MOD_RES 1102 1102 Phosphoserine.
MOD_RES 1353 1353 Phosphoserine.
MOD_RES 1355 1355 Phosphoserine.
MOD_RES 1356 1356 Phosphoserine.
MOD_RES 1360 1360 Phosphoserine.
MOD_RES 1363 1363 Phosphoserine.
MOD_RES 1371 1371 Phosphoserine.
MOD_RES 1677 1677 Phosphoserine. |
Keyword | 3D-structure; Alternative splicing; ATP-binding; Chromatin regulator; Complete proteome; Cytoplasm; DNA-binding; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1710 AA |
Protein Sequence | MNGHSDEESV RNSSGESSQS DDDSGSASGS GSGSSSGSSS DGSSSQSGSS DSDSGSESGS 60
QSESESDTSR ENKVQAKPPK VDGAEFWKSS PSILAVQRSA ILKKQQQQQQ QQQHQASSNS 120
GSEEDSSSSE DSDDSSSEVK RKKHKDEDWQ MSGSGSPSQS GSDSESEEER EKSSCDETES 180
DYEPKNKVKS RKPQNRSKSK NGKKILGQKK RQIDSSEEDD DEEDYDNDKR SSRRQATVNV 240
SYKEDEEMKT DSDDLLEVCG EDVPQPEEEE FETIERFMDC RIGRKGATGA TTTIYAVEAD 300
GDPNAGFEKN KEPGEIQYLI KWKGWSHIHN TWETEETLKQ QNVRGMKKLD NYKKKDQETK 360
RWLKNASPED VEYYNCQQEL TDDLHKQYQI VERIIAHSNQ KSAAGYPDYY CKWQGLPYSE 420
CSWEDGALIS KKFQACIDEY FSRNQSKTTP FKDCKVLKQR PRFVALKKQP SYIGGHEGLE 480
LRDYQLNGLN WLAHSWCKGN SCILADEMGL GKTIQTISFL NYLFHEHQLY GPFLLVVPLS 540
TLTSWQREIQ TWASQMNAVV YLGDINSRNM IRTHEWTHHQ TKRLKFNILL TTYEILLKDK 600
AFLGGLNWAF IGVDEAHRLK NDDSLLYKTL IDFKSNHRLL ITGTPLQNSL KELWSLLHFI 660
MPEKFSSWED FEEEHGKGRE YGYASLHKEL EPFLLRRVKK DVEKSLPAKV EQILRMEMSA 720
LQKQYYKWIL TRNYKALSKG SKGSTSGFLN IMMELKKCCN HCYLIKPPDN NEFYNKQEAL 780
QHLIRSSGKL ILLDKLLIRL RERGNRVLIF SQMVRMLDIL AEYLKYRQFP FQRLDGSIKG 840
ELRKQALDHF NAEGSEDFCF LLSTRAGGLG INLASADTVV IFDSDWNPQN DLQAQARAHR 900
IGQKKQVNIY RLVTKGSVEE DILERAKKKM VLDHLVIQRM DTTGKTVLHT GSAPSSSTPF 960
NKEELSAILK FGAEELFKEP EGEEQEPQEM DIDEILKRAE THENEPGPLT VGDELLSQFK 1020
VANFSNMDED DIELEPERNS KNWEEIIPED QRRRLEEEER QKELEEIYML PRMRNCAKQI 1080
SFNGSEGRRS RSRRYSGSDS DSISEGKRPK KRGRPRTIPR ENIKGFSDAE IRRFIKSYKK 1140
FGGPLERLDA IARDAELVDK SETDLRRLGE LVHNGCIKAL KDSSSGTERT GGRLGKVKGP 1200
TFRISGVQVN AKLVISHEEE LIPLHKSIPS DPEERKQYTI PCHTKAAHFD IDWGKEDDSN 1260
LLIGIYEYGY GSWEMIKMDP DLSLTHKILP DDPDKKPQAK QLQTRADYLI KLLSRDLAKK 1320
EALSGAGSSK RRKARAKKNK AMKSIKVKEE IKSDSSPLPS EKSDEDDDKL SESKSDGRER 1380
SKKSSVSDAP VHITASGEPV PISEESEELD QKTFSICKER MRPVKAALKQ LDRPEKGLSE 1440
REQLEHTRQC LIKIGDHITE CLKEYTNPEQ IKQWRKNLWI FVSKFTEFDA RKLHKLYKHA 1500
IKKRQESQQN SDQNSNLNPH VIRNPDVERL KENTNHDDSS RDSYSSDRHL TQYHDHHKDR 1560
HQGDSYKKSD SRKRPYSSFS NGKDHRDWDH YKQDSRYYSD REKHRKLDDH RSRDHRSNLE 1620
GSLKDRSHSD HRSHSDHRLH SDHRSSSEYT HHKSSRDYRY HSDWQMDHRA SSSGPRSPLD 1680
QRSPYGSRSP FEHSVEHKST PEHTWSSRKT 1710 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004003; F:ATP-dependent DNA helicase activity; TAS:ProtInc. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0035064; F:methylated histone residue binding; IDA:UniProtKB. GO:0006338; P:chromatin remodeling; IEA:Compara. GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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SMART | |
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