| Tag | Content |
|---|
| CPLM ID | CPLM-005475 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Carbamoyl-phosphate synthase pyrimidine-specific large chain |
Protein Synonyms/Alias | Carbamoyl-phosphate synthetase ammonia chain |
Gene Name | pyrAB |
Gene Synonyms/Alias | BSU15520 |
Created Date | July 27, 2013 |
Organism | Bacillus subtilis (strain 168) |
NCBI Taxa ID | 224308 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 422 | ISDELLEKRIKKAGD | acetylation | [1] | | 751 | IDRYLTGKEIEVDAV | acetylation | [1] |
|
Reference | [1] The acetylproteome of Gram-positive model bacterium Bacillus subtilis. Kim D, Yu BJ, Kim JA, Lee YJ, Choi SG, Kang S, Pan JG. Proteomics. 2013 May;13(10-11):1726-36. [ PMID: 23468065] |
Functional Description | |
Sequence Annotation | DOMAIN 133 327 ATP-grasp 1.
DOMAIN 671 861 ATP-grasp 2.
NP_BIND 159 216 ATP (By similarity).
NP_BIND 697 754 ATP (By similarity).
REGION 1 401 Carboxyphosphate synthetic domain.
REGION 402 546 Oligomerization domain.
REGION 547 929 Carbamoyl phosphate synthetic domain.
REGION 930 1071 Allosteric domain.
METAL 284 284 Magnesium or manganese 1 (By similarity).
METAL 298 298 Magnesium or manganese 1 (By similarity).
METAL 298 298 Magnesium or manganese 2 (By similarity).
METAL 300 300 Magnesium or manganese 2 (By similarity).
METAL 820 820 Magnesium or manganese 3 (By similarity).
METAL 832 832 Magnesium or manganese 3 (By similarity).
METAL 832 832 Magnesium or manganese 4 (By similarity).
METAL 834 834 Magnesium or manganese 4 (By similarity). |
Keyword | ATP-binding; Complete proteome; Ligase; Magnesium; Manganese; Metal-binding; Nucleotide-binding; Pyrimidine biosynthesis; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1071 AA |
Protein Sequence | MPKRVDINKI LVIGSGPIII GQAAEFDYAG TQACLALKEE GYEVILVNSN PATIMTDTEM 60
ADRVYIEPLT PEFLTRIIRK ERPDAILPTL GGQTGLNLAV ELSERGVLAE CGVEVLGTKL 120
SAIQQAEDRD LFRTLMNELN EPVPESEIIH SLEEAEKFVS QIGFPVIVRP AYTLGGTGGG 180
ICSNETELKE IVENGLKLSP VHQCLLEKSI AGYKEIEYEV MRDSQDHAIV VCNMENIDPV 240
GIHTGDSIVV APSQTLSDRE YQLLRNVSLK LIRALGIEGG CNVQLALDPD SFQYYIIEVN 300
PRVSRSSALA SKATGYPIAK LAAKIAVGLS LDEMMNPVTG KTYAAFEPAL DYVVSKIPRW 360
PFDKFESANR KLGTQMKATG EVMAIGRTLE ESLLKAVRSL EADVYHLELK DAADISDELL 420
EKRIKKAGDE RLFYLAEAYR RGYTVEDLHE FSAIDVFFLH KLFGIVQFEK ELKANAGDTD 480
VLRRAKELGF SDQYISREWK MKESELYSLR KQAGIAPVFK MVDTCAAEFE SETPYFYSTY 540
EEENESVVTD KKSVMVLGSG PIRIGQGVEF DYATVHSVWA IKQAGYEAII VNNNPETVST 600
DFSISDKLYF EPLTIEDVMH IIDLEQPMGV VVQFGGQTAI NLADELSARG VKILGTSLED 660
LDRAEDRDKF EQALGELGVP QPLGKTATSV NQAVSIASDI GYPVLVRPSY VLGGRAMEIV 720
YHEEELLHYM KNAVKINPQH PVLIDRYLTG KEIEVDAVSD GETVVIPGIM EHIERAGVHS 780
GDSIAVYPPQ SLTEDIKKKI EQYTIALAKG LNIVGLLNIQ FVLSQGEVYV LEVNPRSSRT 840
VPFLSKITGI PMANLATKII LGQKLAAFGY TEGLQPEQQG VFVKAPVFSF AKLRRVDITL 900
GPEMKSTGEV MGKDSTLEKA LYKALIASGI QIPNYGSVLL TVADKDKEEG LAIAKRFHAI 960
GYNILATEGT AGYLKEASIP AKVVGKIGQD GPNLLDVIRN GEAQFVINTL TKGKQPARDG 1020
FRIRRESVEN GVACLTSLDT AEAILRVLES MTFRADQMPA VNTNQEAAVT I 1071 |
Gene Ontology | GO:0005524; F:ATP binding; IEA:HAMAP. GO:0004088; F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; IEA:HAMAP. GO:0000287; F:magnesium ion binding; IEA:HAMAP. GO:0030145; F:manganese ion binding; IEA:HAMAP. GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway. GO:0006526; P:arginine biosynthetic process; IEA:HAMAP. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |