| Tag | Content |
|---|
| CPLM ID | CPLM-002474 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial |
Protein Synonyms/Alias | P5C dehydrogenase |
Gene Name | PUT2 |
Gene Synonyms/Alias | YHR037W |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 42 | PFRNIDLKDWDLLRA | acetylation | [1] | | 55 | RASLMKFKSSSLEVP | acetylation | [1] | | 307 | QSGVVEGKYRDYPRI | acetylation | [1] | | 410 | IHEQSFDKLVKVIED | acetylation | [1] | | 413 | QSFDKLVKVIEDAKK | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | |
Sequence Annotation | NP_BIND 297 302 NAD (By similarity).
ACT_SITE 317 317 Proton acceptor (By similarity).
ACT_SITE 351 351 Nucleophile (By similarity). |
Keyword | Complete proteome; Membrane; Mitochondrion; Mitochondrion inner membrane; NAD; Oxidoreductase; Proline metabolism; Reference proteome; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 575 AA |
Protein Sequence | MLSARCLKSI YFKRSFSQLG HIKPPKHIRN EPVKPFRNID LKDWDLLRAS LMKFKSSSLE 60
VPLVINGERI YDNNERALFP QTNPANHQQV LANVTQATEK DVMNAVKAAK DAKKDWYNLP 120
FYDRSAIFLK AADLISTKYR YDMLAATMLG QGKNVYQAEI DCITELSDFF RYYVKYASDL 180
YAQQPVESAD GTWNKAEYRP LEGFVYAVSP FNFTAIAANL IGAPALMGNT VVWKPSQTAA 240
LSNYLLMTVL EEAGLPKGVI NFIPGDPVQV TDQVLADKDF GALHFTGSTN VFKSLYGKIQ 300
SGVVEGKYRD YPRIIGETGG KNFHLVHPSA NISHAVLSTI RGTFEFQGQK CSAASRLYLP 360
ESKSEEFLSD MFGILQSQNV VPMNTSASPI SGGNLRGFMG PVIHEQSFDK LVKVIEDAKK 420
DPELEILYGG QYDKSQGWFV GPTVIKAKRP DHPYMSTEFF GPILTVYEYP DTEFNEICDI 480
IDNTSQYALT GAIFAKDRKA IEYADEKLKF SAGNFYINDK CTGAVVSQQW FGGARMSGTD 540
DKAGGPNILS RFVSIRNTKE NFYELTDFKY PSNYE 575 |
Gene Ontology | GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. GO:0005759; C:mitochondrial matrix; IDA:SGD. GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IDA:SGD. GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro. GO:0006537; P:glutamate biosynthetic process; IDA:SGD. GO:0006561; P:proline biosynthetic process; IEA:InterPro. GO:0010133; P:proline catabolic process to glutamate; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |